Comparative analysis of morphological and hemodynamic parameters in stable anterior communicating and middle cerebral artery aneurysms

Abstract

Objective: This study investigates morphological, hemodynamic and structural mechanical factors influencing aneurysm rupture behavior, specifically focusing on Middle Cerebral Artery (MCA) and Anterior Communicating Artery (ACOMM) aneurysms, using computational fluid dynamics (CFD) and fluid-structure interaction (FSI) analyses.

Methods: Data from 116 patients with aneurysms located in the MCA and ACOMM, including 81 ruptured and 35 stable aneurysms. Aneurysms were modeled with FSI methods to examine key parameters: aneurysm angle, wall shear stress, and equivalent Mises stress as well as additional parameters. Statistical analyses were conducted using the Mann-Whitney U-test to identify significant differences in these parameters between the two locations in stable and ruptured aneurysms. In a further step univariate and multivariate regression analysis was performed.

Results: Results indicated no significant differences in the assessed parameters between ruptured MCA and ACOMM aneurysms. However, stable ACOMM aneurysms exhibited a larger aneurysm angle, lower wall equivalent stress as well as lower ratio of maximum WSS in the aneurysms and the parent vessel when compared to MCA aneurysms, indicating that ACOMM aneurysms may rupture at lower stresses possibly due to their higher aneurysm angle. Regression analysis underlines the statistical power of aneurysm angle.

Conclusions: These findings highlight morphological and hemodynamic differences in stable aneurysms across MCA and ACOMM locations. Stable MCA aneurysms appear to tolerate higher wall stress values compared to ACOMM aneurysms, leading to greater susceptibility to rupture in ACOMM aneurysms at stress levels where MCA aneurysms can remain stable. This study underscores the importance of considering morphological, hemodynamic and structural mechanical factors as well as the distinction between stable and ruptured aneurysms, to improve the accuracy of rupture risk.

Keywords: Anterior Communicating Artery; Fluid-Structure interaction; Middle Cerebral Artery; cerebral aneurysms.