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. 1985 Aug;316(6029):606-9.
doi: 10.1038/316606a0.

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

P S Ohashi, T W Mak, P Van den Elsen, Y Yanagi, Y Yoshikai, A F Calman, C Terhorst, J D Stobo, A Weiss

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

P S Ohashi et al. Nature. 1985 Aug.

Abstract

We have introduced a full-length complementary DNA of the T-cell antigen receptor beta-chain into a mutant human T-cell line that lacked a complete beta-chain messenger RNA, had a diminished level of alpha-chain transcript and did not express surface T3- or antigen receptor. Expression of the transfected beta-chain led to a normal level of alpha-chain transcript and a structurally and functionally active T3 T-cell antigen receptor complex on the cell surface.

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