Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 1;11(7):796-797.
doi: 10.1001/jamaoncol.2025.0901.

Prophylactic Irradiation of the Contralateral Breast for BRCA Carriers With Early Breast Cancer: A Nonrandomized Clinical Trial

Affiliations

Prophylactic Irradiation of the Contralateral Breast for BRCA Carriers With Early Breast Cancer: A Nonrandomized Clinical Trial

Ella Evron et al. JAMA Oncol. .
No abstract available

Plain language summary

This nonrandomized phase 2 clinical trial examines contralateral breast cancer risk reduction in women who choose radiation therapy or surveillance rather than mastectomy.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: None reported.

References

    1. Kuchenbaecker KB, Hopper JL, Barnes DR, et al. ; BRCA1 and BRCA2 Cohort Consortium . Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 2017;317(23):2402-2416. doi: 10.1001/jama.2017.7112 - DOI - PubMed
    1. Nara M, Ishihara S, Kitano A, et al. Does breast-conserving surgery with radiotherapy in BRCA-mutation carriers significantly increase ipsilateral breast tumor recurrence? a systematic review and meta-analysis. Breast Cancer. 2022;29(3):394-401. doi: 10.1007/s12282-022-01343-3 - DOI - PubMed
    1. Davey MG, Davey CM, Ryan ÉJ, Lowery AJ, Kerin MJ. Combined breast conservation therapy versus mastectomy for BRCA mutation carriers - a systematic review and meta-analysis. Breast. 2021;56:26-34. doi: 10.1016/j.breast.2021.02.001 - DOI - PMC - PubMed
    1. Yip CH, Newman LA. American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology guideline for management of hereditary breast cancer. JAMA Surg. 2021;156(3):284-285. doi: 10.1001/jamasurg.2020.6254 - DOI - PubMed
    1. Evron E, Ben-David AM, Goldberg H, et al. Prophylactic irradiation to the contralateral breast for BRCA mutation carriers with early-stage breast cancer. Ann Oncol. 2019;30(3):412-417. doi: 10.1093/annonc/mdy515 - DOI - PubMed

LinkOut - more resources