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This nonrandomized phase 2 clinical trial examines contralateral breast cancer risk reduction in women who choose radiation therapy or surveillance rather than mastectomy.
Kuchenbaecker KB, Hopper JL, Barnes DR, et al. ; BRCA1 and BRCA2 Cohort Consortium . Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 2017;317(23):2402-2416. doi: 10.1001/jama.2017.7112
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Nara M, Ishihara S, Kitano A, et al. Does breast-conserving surgery with radiotherapy in BRCA-mutation carriers significantly increase ipsilateral breast tumor recurrence? a systematic review and meta-analysis. Breast Cancer. 2022;29(3):394-401. doi: 10.1007/s12282-022-01343-3
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Davey MG, Davey CM, Ryan ÉJ, Lowery AJ, Kerin MJ. Combined breast conservation therapy versus mastectomy for BRCA mutation carriers - a systematic review and meta-analysis. Breast. 2021;56:26-34. doi: 10.1016/j.breast.2021.02.001
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Yip CH, Newman LA. American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology guideline for management of hereditary breast cancer. JAMA Surg. 2021;156(3):284-285. doi: 10.1001/jamasurg.2020.6254
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Evron E, Ben-David AM, Goldberg H, et al. Prophylactic irradiation to the contralateral breast for BRCA mutation carriers with early-stage breast cancer. Ann Oncol. 2019;30(3):412-417. doi: 10.1093/annonc/mdy515
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