Intrinsic Ketogenic Capacity of the Heart: Mechanisms and Therapeutic Potential

Rosanna Caputo^{1

2}, Carolina Magdalen Greco^{1

2}

Affiliations

¹ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (R.C., C.M.G.).
² Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy (R.C., C.M.G.).

Editorial

Rosanna Caputo et al. Circ Res. 2025.

. 2025 May 9;136(10):1131-1133.

doi: 10.1161/CIRCRESAHA.125.326560. Epub 2025 May 8.

Rosanna Caputo^{1

2}, Carolina Magdalen Greco^{1

2}

¹ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy (R.C., C.M.G.).
² Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan, Italy (R.C., C.M.G.).

No abstract available

Keywords: Editorials; fatty acids; glucose; heart failure; ketone bodies.

Conflict of interest statement

None.

The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD⁺ Therapy in HFpEF.
Koay YC, McIntosh B, Ng YH, Cao Y, Wang XS, Han Y, Tomita S, Bai AY, Hunter B, Misra A, Loughrey CM, Bannon PG, Lal S, Lusis AJ, Kaye DM, Larance M, O'Sullivan JF. Koay YC, et al. Circ Res. 2025 May 9;136(10):1113-1130. doi: 10.1161/CIRCRESAHA.124.325550. Epub 2025 Apr 11. Circ Res. 2025. PMID: 40211954 Free PMC article.