Histone Methyltransferase SETD2: A Key Player in Cardiometabolic HFpEF

Simone Serio^{1

2}, Roberto Papait^{2

3}

Affiliations

¹ Institute of Genetic and Biomedical Research (IRGB), Milan Unit, National Research Council of Italy (S.S.).
² Department of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano, Italy (S.S., R.P.).
³ Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy (R.P.).

Editorial

Simone Serio et al. Circ Res. 2025.

. 2025 May 9;136(10):1096-1098.

doi: 10.1161/CIRCRESAHA.125.326463. Epub 2025 May 8.

Simone Serio^{1

2}, Roberto Papait^{2

3}

¹ Institute of Genetic and Biomedical Research (IRGB), Milan Unit, National Research Council of Italy (S.S.).
² Department of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano, Italy (S.S., R.P.).
³ Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy (R.P.).

No abstract available

Keywords: Editorials; epigenome; heart failure; myocytes, cardiac; obesity; sterol regulatory element binding protein 1.

Conflict of interest statement

None.

Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF.
Costantino S, Mohammed SA, Ambrosini S, Telesca M, Mengozzi A, Walavalkar K, Gorica E, Herwig M, van Heerebeek L, Xia J, Karsai G, Hornemann T, Dzemali O, Santoro R, Lin Q, Ruschitzka F, Hamdani N, Paneni F. Costantino S, et al. Circ Res. 2025 May 9;136(10):1079-1095. doi: 10.1161/CIRCRESAHA.124.325310. Epub 2025 Apr 11. Circ Res. 2025. PMID: 40211947