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Editorial
. 2025 Sep-Oct;51(5):e20250223.
doi: 10.1590/S1677-5538.IBJU.2025.0223.

Male Infertility: Diagnostic Approach - A Committee Opinion

Sandro C Esteves  1   2 , Marina C Viana  1 , Augusto B Reis  3   4 , Filipe Tenório Lira Neto  5   6 , Thiago Afonso Teixeira  7   8   9 , João Paulo Camarço  10   11 , Matheus Gröner  12   13 , Antônio José T Paula  14   15 , Alberto C Stein  16 , Maria Gabriela F Mulato  1 , Jorge Hallak  8   9   17   18   19 , Renato Fraietta  12   13
Affiliations
Editorial

Male Infertility: Diagnostic Approach - A Committee Opinion

Sandro C Esteves et al. Int Braz J Urol. 2025 Sep-Oct.
No abstract available

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Goals of the male infertility diagnostic approach, including identifying correctable and irreversible conditions, recognizing when donor insemination or adoption are necessary, detecting health-threatening comorbidities, and uncovering genetic or lifestyle factors that may impact patient or offspring health, especially in the context of assisted reproductive technology (ART).
Figure 2
Figure 2
Algorithm for the initial evaluation of the male partner in an infertile couple. The process begins with a thorough medical, sexual, and reproductive history, followed by a focused physical examination. At least two semen analyses should be obtained according to WHO guidelines. Subsequent steps include laboratory testing (e.g., hormonal profile, genetic testing), imaging, and extended sperm function testing, including sperm DNA fragmentation analysis, as clinically indicated. The goal is to guide diagnosis and management tailored to the identified abnormalities.
See this image and copyright information in PMC

References

    1. Eisenberg ML, Esteves SC, Lamb DJ, Hotaling JM, Giwercman A, Hwang K, Cheng YS. Male infertility. Nat Rev Dis Primers. 2023;9:49–49. doi: 10.1038/s41572-023-00459-w. - DOI - PubMed
    1. Esteves SC, Humaidan P. Towards infertility care on equal terms: a prime time for male infertility. Reprod Biomed Online. 2023;47:11–14. doi: 10.1016/j.rbmo.2023.04.003. - DOI - PubMed
    1. Minhas S, Boeri L, Capogrosso P, Cocci A, Corona G, Dinkelman-Smit M, Falcone M, Jensen CF, Gül M, Kalkanli A, Kadioğlu A, Martinez-Salamanca JI, Morgado LA, Russo GI, Serefoğlu EC, Verze P, Salonia A. European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2025 Update on Male Infertility. Eur Urol. 2025;87:601–616. doi: 10.1016/j.eururo.2025.02.026. - DOI - PubMed
    1. Brannigan RE, Hermanson L, Kaczmarek J, Kim SK, Kirkby E, Tanrikut C. Updates to Male Infertility: AUA/ASRM Guideline (2024) J Urol. 2024;212:789–799. doi: 10.1097/JU.0000000000004180. - DOI - PubMed
    1. Fraga LG, Gismondi JP, Sanvido LV, Lozano AFQ, Teixeira TA, Hallak J. Clinical and laboratorial evaluation of male infertility. A Detailed Practical Approach. Arch Med Res. 2024;55:103139–103139. - PubMed

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