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. 2025 May 8;29(1):183.
doi: 10.1186/s13054-025-05334-6.

Association between plasma catecholamine concentration and mortality in hospitalized adults with COVID-19: a secondary analysis of a multicenter randomized trial

Basmah Safdar  1 , Gary Desir  2 , Bin Zhou  3 , Yanhong Deng  3 , Xiaojia Guo  2 , D Clark Files  4 , Laurence W Busse  5 , Matthew Shotwell  6 , Mark C Chappell  7 , Wesley H Self  8   9 , Sean P Collins  9   10 ; ACTIV-4 Host Tissue Investigators
Collaborators, Affiliations

Association between plasma catecholamine concentration and mortality in hospitalized adults with COVID-19: a secondary analysis of a multicenter randomized trial

Basmah Safdar et al. Crit Care. .
No abstract available

Keywords: Angiotensin; Catecholamines; Cytokine; Mortality; Norepinephrine; Severe COVID-19.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: All patients provided written informed consent. The study was approved by the Vanderbilt University IRB. Consent for publication: This study does not include individual persons’ data. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
(a) Multivariable Cox Regression Model of Norepinephrine and Mortality in patients hospitalized with COVID-19, and (b) Kaplan–Meier Survival Curves for Mortality Events and Norepinephrine (by Trend of Change) adjusted for covariates
See this image and copyright information in PMC

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