Allogeneic anti-CD19 CAR-T cells induce remission in refractory systemic lupus erythematosus

Chunmei Yang^#¹, Chuanyin Sun^#², Binghe Tan^#^{3

4}, Chao Hu¹, Liyan Wan², Chris Wang⁴, Xiujuan Shi⁴, Juliang Qin³, Na Zhang⁴, Biao Zheng⁴, Mingyao Liu^{5

6}, Jin Lin⁷, Bing Du^{8

9}, Hongyan Tong^{10

11

12}

Affiliations

¹ Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
² Department of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
³ Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China.
⁴ BRL Medicine Inc., Shanghai, China.
⁵ Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China. myliu@bio.ecnu.edu.cn.
⁶ BRL Medicine Inc., Shanghai, China. myliu@bio.ecnu.edu.cn.
⁷ Department of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. linjinzju@zju.edu.cn.
⁸ Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China. bdu@bio.ecnu.edu.cn.
⁹ BRL Medicine Inc., Shanghai, China. bdu@bio.ecnu.edu.cn.
¹⁰ Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. tonghongyan@zju.edu.cn.
¹¹ Zhejiang Provincial Clinical Research Center for Hematologic Diseases, Hangzhou, Zhejiang, China. tonghongyan@zju.edu.cn.
¹² Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, Zhejiang, China. tonghongyan@zju.edu.cn.

^# Contributed equally.

PMID: 40341741
PMCID: PMC12297247
DOI: 10.1038/s41422-025-01128-1

Allogeneic anti-CD19 CAR-T cells induce remission in refractory systemic lupus erythematosus

Chunmei Yang et al. Cell Res. 2025 Aug.

. 2025 Aug;35(8):607-609.

doi: 10.1038/s41422-025-01128-1. Epub 2025 May 8.

Authors

Affiliations

¹ Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
² Department of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
³ Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China.
⁴ BRL Medicine Inc., Shanghai, China.
⁵ Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China. myliu@bio.ecnu.edu.cn.
⁶ BRL Medicine Inc., Shanghai, China. myliu@bio.ecnu.edu.cn.
⁷ Department of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. linjinzju@zju.edu.cn.
⁸ Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China. bdu@bio.ecnu.edu.cn.
⁹ BRL Medicine Inc., Shanghai, China. bdu@bio.ecnu.edu.cn.
¹⁰ Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. tonghongyan@zju.edu.cn.
¹¹ Zhejiang Provincial Clinical Research Center for Hematologic Diseases, Hangzhou, Zhejiang, China. tonghongyan@zju.edu.cn.
¹² Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, Zhejiang, China. tonghongyan@zju.edu.cn.