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. 2025 Jun;16(3):e13820.
doi: 10.1002/jcsm.13820.

Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population

Kentaro Ikeue  1   2 , Hisashi Kato  1 , Masashi Tanaka  1   3 , Hajime Yamakage  1 , Sayaka Kato  1 , Masayo Iwasa  1 , Kan Oishi  4 , Yuiko Yamamoto  2 , Megumi Kanasaki  5 , Izuru Masuda  1   6 , Kojiro Ishii  4 , Noriko Satoh-Asahara  1
Affiliations

Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population

Kentaro Ikeue et al. J Cachexia Sarcopenia Muscle. 2025 Jun.

Abstract

Background: Sarcopenia is associated with an increased risk for dementia. This study aimed to elucidate the relationship between sarcopenia-related indices and cognitive decline in the general population.

Methods: This was a cross-sectional study involving 263 participants (163 men with a median age of 60 years [interquartile range = 53-70] and 100 women with a median age of 58 years [interquartile range = 49-68]) who underwent a general health examination. Sarcopenia-related indices included appendicular skeletal muscle mass (ASM)/height2, ASM/body mass index, handgrip strength (HGS), HGS/upper extremity skeletal muscle mass and phase angle (PhA). We examined the associations between these indices and cognitive function using the Japanese version of the Montreal Cognitive Assessment (MoCA-J).

Results: Higher PhA, an indicator of muscle quality, was associated with a lower risk of mild cognitive impairment (MCI) in women (adjusted odds ratio = 0.28 [95% confidence interval, 0.10-0.78], p = 0.014), whereas the other sarcopenia-related indices showed no significant association with MCI in both sexes. The PhA of women was positively associated with the MoCA-J scores (β = 0.27, p = 0.005). Moreover, the PhA of women showed a positive correlation with cognitive subdomains, including memory (r = 0.22, p = 0.031), which is one of the earliest manifestations of cognitive impairment. The PhA in men was also positively correlated with memory (r = 0.24, p = 0.002).

Conclusions: PhA is a potentially novel index for detecting the risk of sarcopenia and cognitive decline in the general population.

Keywords: bioimpedance analysis; cognitive decline; memory; muscle quality; phase angle.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Study flow chart of participants.
FIGURE 2
FIGURE 2
Association between a sarcopenia‐related index and MCI in all participants. Relationships between sarcopenia‐related indices and MCI are shown in unadjusted, sex‐adjusted and sex‐ and age‐adjusted models. MCI, mild cognitive impairment; OR, odds ratio; CI, confidence interval; SMI, skeletal muscle mass index; ASM, appendicular skeletal muscle mass; BMI, body mass index; HGS, handgrip strength; USM, upper extremity skeletal muscle mass; PhA, phase angle.
FIGURE 3
FIGURE 3
Association between a sarcopenia‐related index and MCI in subgroups categorized by sex. Relationships between sarcopenia‐related indices and MCI in the sex‐categorized subgroups are shown in unadjusted (left panel) and age‐adjusted (right panel) models. MCI, mild cognitive impairment; OR, odds ratio; CI, confidence interval; SMI, skeletal muscle mass index; ASM, appendicular skeletal muscle mass; BMI, body mass index; HGS, handgrip strength; USM, upper extremity skeletal muscle mass; PhA, phase angle.
See this image and copyright information in PMC

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