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. 2025 May 8;13(5):e70501.
doi: 10.1002/ccr3.70501. eCollection 2025 May.

Successful and Sustained Treatment of Cutaneous Tumoral Lesions in Brooke-Spiegler Syndrome (BSS) Using Ablative CO2 Laser: A Case Series and Literature Review

Nikoo Mozafari  1   2 , Mohammad Amin Jafari  3 , Shirin Zaresharifi  1 , Hassan Vahidnezhad  4   5   6 , Leila Youssefian  7   8 , Elham Behrangi  3 , Farnoosh Seirafianpour  9 , Arash Pour Mohammad  10 , Alireza Jafarzadeh  3 , Azadeh Goodarzi  3
Affiliations

Successful and Sustained Treatment of Cutaneous Tumoral Lesions in Brooke-Spiegler Syndrome (BSS) Using Ablative CO2 Laser: A Case Series and Literature Review

Nikoo Mozafari et al. Clin Case Rep. .

Abstract

Continuous-wave CO2 laser therapy is an effective and safe treatment for trichoepitheliomas in Brooke-Spiegler syndrome, improving lesion color, texture, and overall appearance. This non-invasive approach offers high patient satisfaction and demonstrated no recurrence during a 2-year follow-up, making it a promising alternative to surgical excision.

Keywords: Brooke–Spiegler syndrome; CYLD; adnexal tumors; dermatology; trichoepitheliomas.

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Conflict of interest statement

Transparency declaration: The authors affirm that the manuscript is honest, accurate, and transparent. No important aspect of the study has been omitted.The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Histopathological views of trichoepitheliomas in Case 1 (A–C), Case 2 (D–F), and Case 3 (G, H).
FIGURE 2
FIGURE 2
Photographs of trichoepithelioma lesions before and after treatment with two sessions of continuous‐wave CO2 laser therapy in Case 1 (A), Case 2 (B), and Case 3 (C).
See this image and copyright information in PMC

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