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Editorial
. 2025 Apr 1;14(2):290-294.
doi: 10.21037/hbsn-2024-716. Epub 2025 Mar 25.

Resmetirom as an important cornerstone of multidisciplinary management of metabolic dysfunction-associated steatohepatitis

Affiliations
Editorial

Resmetirom as an important cornerstone of multidisciplinary management of metabolic dysfunction-associated steatohepatitis

Kahei Au et al. Hepatobiliary Surg Nutr. .
No abstract available

Keywords: Obesity; bariatric surgery; lifestyle intervention; medication; non-alcoholic fatty liver disease.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-2024-716/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Recommended dietary patterns in MASLD/MASH patients. The MD and LFD is suggested to use in combination with physical exercise for personalized lifestyle intervention, which can significantly improve visceral fat, and have similar therapeutic effects on liver enzymes and liver fat content. Created in BioRender. Au K. [2024]. BioRender.com/g95h140. ↑, increase; ↓, decrease. LFD, low-fat diet; MASH, metabolic dysfunction-associated steatohepatitis; MASLD, metabolic dysfunction-associated steatotic liver disease; MD, Mediterranean diet.
Figure 2
Figure 2
Procedures and diagrams of SG and RYGB. The SG and RYGB is mainly suggested to use in MBS for obesity and diabetes, efficacy and safety MBS in patients with MASH has also been progressively proven. Created in BioRender. Au K. [2024]. BioRender.com/c49i939. MASH, metabolic dysfunction-associated steatohepatitis; MBS, metabolic and bariatric surgery; RYGB, Roux-en-Y gastric bypass; SG, sleeve gastrectomy.

Comment on

References

    1. Harrison SA, Taub R, Neff GW, et al. Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial. Nat Med 2023;29:2919-28. 10.1038/s41591-023-02603-1 - DOI - PMC - PubMed
    1. Luo L, Ye J, Zhuo S, et al. Specific metabolic impairments indicate loss of sustained liver improvements in metabolic dysfunction-associated steatotic liver disease treatment. Hepatobiliary Surg Nutr 2024;13:632-49. 10.21037/hbsn-23-393 - DOI - PMC - PubMed
    1. Katsagoni CN, Georgoulis M, Papatheodoridis GV, et al. Effects of lifestyle interventions on clinical characteristics of patients with non-alcoholic fatty liver disease: A meta-analysis. Metabolism 2017;68:119-32. 10.1016/j.metabol.2016.12.006 - DOI - PubMed
    1. George ES, Reddy A, Nicoll AJ, et al. Impact of a Mediterranean diet on hepatic and metabolic outcomes in non-alcoholic fatty liver disease: The MEDINA randomised controlled trial. Liver Int 2022;42:1308-22. 10.1111/liv.15264 - DOI - PMC - PubMed
    1. Xiong Y, Shi X, Xiong X, et al. A systematic review and meta-analysis of randomized controlled trials: effects of mediterranean diet and low-fat diet on liver enzymes and liver fat content of NAFLD. Food Funct 2024;15:8248-57. 10.1039/d4fo01461h - DOI - PubMed

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