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Review
. 2025 May;8(5):e70215.
doi: 10.1002/cnr2.70215.

Recurrent Malignant Melanoma on the Tongue: A Case Report and Review of the Literature

Maziar Motiee-Langroudi  1 , Athena Farahzadi  2 , Pouyan Aminshakib  3
Affiliations
Review

Recurrent Malignant Melanoma on the Tongue: A Case Report and Review of the Literature

Maziar Motiee-Langroudi et al. Cancer Rep (Hoboken). 2025 May.

Abstract

Background: Melanoma of the oral mucosa is an uncommon cancer arising from the tissues lining the mouth. Among oronasal malignant melanomas, tongue melanoma makes up a mere 2%. Optimal treatments for this rare and often late-stage disease remain elusive. However, surgery with free margins is considered the primary treatment and is often combined with other therapies such as neck dissection, adjuvant radiotherapy, chemotherapy, and immunotherapy.

Case: This case involves a 33-year-old woman with a history of malignant melanoma on her tongue. She had previously undergone a partial glossectomy and was on maintenance imatinib treatment for ~2 years. During her follow-up, a new lesion was discovered on her tongue, which was confirmed to be malignant melanoma and was resected. The tumor exhibited a depth of invasion of 8 mm. All surgical margins were clear, with the closest margin being 3 mm. The lesion was reconstructed with a submental flap. Adjuvant radiotherapy was also given. The patient has been on maintenance follow-up for 3 years with no signs of recurrence.

Conclusion: Malignant melanoma should be considered in the differential diagnosis of pigmented and non-pigmented lesions of the tongue and oral mucosa. A thorough clinical evaluation, followed by histopathological and immunohistochemical examination of any suspicious lesions, is essential for early diagnosis. Early detection and prompt treatment are crucial for optimizing patient outcomes and improving survival rates.

Keywords: mucosal melanoma; recurrent tongue melanoma; tongue malignant melanoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Intraoperative view of the surgical defect in the posterolateral tongue (Top). Resected tongue tissue specimen (Bottom).
FIGURE 2
FIGURE 2
Photomicrographs show infiltrative nests of haphazardly arranged neoplastic cells (A: ×40), demonstrating significant nuclear pleomorphism and prominent aggregation of melanin pigment (B: ×100).
See this image and copyright information in PMC

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