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. 2025 Jun 9;43(6):1004-1006.
doi: 10.1016/j.ccell.2025.04.005. Epub 2025 May 8.

Immune evolution in pre-invasive lung adenocarcinoma

Adithya Balasubramanian  1 , Marie-Liesse Asselin-Labat  2
Affiliations

Immune evolution in pre-invasive lung adenocarcinoma

Adithya Balasubramanian et al. Cancer Cell. .

Abstract

The mechanisms governing the progression of precursor lesions to invasive lung adenocarcinoma (LUAD) remain poorly understood. In this issue of Cancer Cell, Zhu et al. map the dynamic immune changes associated with this progression using high-resolution spatial mapping. Their identification of TIM-3 as a potential target may shift strategies for LUAD immunoprevention.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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