Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May 9;15(1):16229.
doi: 10.1038/s41598-025-00704-0.

Relationship of serum phosphorus level with acute cerebrovascular disease

Sami Ataman  1 , Abdullah Sadık Girişgin  2 , Mustafa Kürşat Ayranci  2 , Kadir Küçükceran  2
Affiliations

Relationship of serum phosphorus level with acute cerebrovascular disease

Sami Ataman et al. Sci Rep. .

Abstract

There are no sufficient studies on laboratory parameters associated with acute stroke. Laboratory parameters associated with acute stroke may become important in the prevention or follow-up of the disease. To investigate the relationship between cerebrovascular disease (CVD) and serum phosphorus levels. This study was conducted prospectively to evaluate the relationship between cerebrovascular disease and phosphorus in patients who applied to the Emergency Medicine Clinic of the Faculty of Medicine Hospital and underwent central imaging between March 1, 2023, and December 31, 2023. 299 patients who applied to the university emergency department were prospectively included in the study with brain computed tomography (CT) and diffusion magnetic resonance imaging (MRI). The lactate, white blood cell, hgb, neutrophil, lymphocyte, urea, creatine and phosphorus values ​​of the patients at their first admission were recorded. The patients were divided into two groups: CVD group and control group. The laboratory parameters of the patients were compared according to the groups. In the ROC analysis performed to evaluate the power of laboratory parameters in predicting the diagnosis of CVD, the AUC value of phosphorus was obtained as 0.935, lactate as 0.620 and urea as 0.596. The optimum cut-off value for phosphorus was calculated as 3.47 (mg/dl) and the sensitivity of this cut-off value was found to be 89%, specifically 86.9%, positive predictive value (ppv) as 77.4% and negative predictive value (npv) as 94%. Lactate, urea and phosphorus values were found to be significantly higher in the CVD group compared to the control group. With this study, we found that serum phosphorus levels were higher than our cut-off value in patients with acute ischemic CVD. We believe that serum phosphorus level will be useful in excluding acute cerebrovascular disease due to its high negative predictive value when evaluated according to the cut-off value of 3.47 (mg/dl).

Keywords: Ischemic CVD; Laboratory; Phosphorus; Stroke.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was approved by the Ethics Committee for Drugs and Medical Devices Non-Interventional Research of Necmettin Erbakan University Faculty of Medicine on 06/03/2023 with decision number 2023/4235. Consent for publication: Patients and/or their relatives were informed that the data obtained from the patients would be used for the article without their names being added and that it could be published in journals worldwide, and written informed consent was obtained from each patient. Human and animal rights: During the research, the World Medical Association (WMA) Declaration of HELSINKI and/ or the World Psychiatric Association HAWAII Declaration of Good Clinical Practice rules were complied with.

Figures

Fig. 1
Fig. 1
ROC curve for the predictive power of phosphorus, lactate, urea in CVO.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Akinyemi, R. O. et al. Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. Brain Res. Bull.145, 97–108. 10.1016/j.brainresbull.2018.05.018 (2019). - PMC - PubMed
    1. Yan, F. et al. Association between triglyceride glucose index and risk of cerebrovascular disease: Systematic review and meta-analysis. Cardiovasc. Diabetes mellitusol.21, 226. 10.1186/s12933-022-01664-9 (2022). - PMC - PubMed
    1. Amarenco, P., Bogousslavsky, J., Caplan, L. R., Donnan, G. A. & Hennerici, M. G. Classification of stroke subtypes. Cerebrovasc. Dis.27(5), 493–501. 10.1159/000210432 (2009). - PubMed
    1. Pathophysiology of Calcium, Phosphorus, and Magnesium Dysregulation in Chronic Kidney Disease - Felsenfeld - 2015 - Seminars in Dialysis - Wiley Online Library. Accessed December 29, 2023. https://onlinelibrary.wiley.com/doi/abs/10.1111/sdi.12411 - PubMed
    1. Mattoo, R. L. The roles of fibroblast growth factor (FGF)-23, α-Klotho and furin protease in calcium and phosphate homeostasis : A mini-review. Indian J. Clin. Biochem.29(1), 8–12. 10.1007/s12291-013-0324-1 (2014). - PMC - PubMed

LinkOut - more resources