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Review
. 2025 Jun;54(2):397-413.
doi: 10.1016/j.gtc.2024.12.005. Epub 2025 Jan 24.

Current Understanding of Optimal Prevention of Helicobacter pylori-Induced Cancer

Adesola Oje  1 , Jonathan Galati  2 , Richard M Peek Jr  2
Affiliations
Review

Current Understanding of Optimal Prevention of Helicobacter pylori-Induced Cancer

Adesola Oje et al. Gastroenterol Clin North Am. 2025 Jun.

Abstract

Gastric cancer is the fifth most common cancer and the fifth most common cause of cancer-related death globally. The key to improving outcomes lies in effective prevention and early detection, which are critical for successful curative interventions. Helicobacter pylori is the strongest known risk factor for gastric cancer, and eradication of this pathogen is critical for reducing cancer risk. By synthesizing current evidence and exploring the advanced therapeutic approaches, this review provides a comprehensive overview of best practices for mitigating gastric cancer through targeted bacterial intervention.

Keywords: Chemoprevention; Gastric cancer; Helicobacter pylori.

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Conflict of interest statement

Disclosure The authors have no potential conflicts (financial, professional, or personal) that are relevant to this article.

Figures

Fig. 1.
Fig. 1.
Correa cascade. (Andrew J. Gawron et al., AGA Technical Review on Gastric Intestinal Metaplasia—Natural History and Clinical Outcomes, Gastroenterology, 158 (3), 2020, 705–731.e5, “https://nam11.safelinks.protection.outlook.com/?url5https%3A%2F%2Fdoi.org%2F10.1053%2Fj.gastro.2019.12.001&data505%7C02%7Cs.kavikumaran%40elsevier.com%7C281915f7c99f4efc1b4008dd3a42c31a%7C9274ee3f94254109a27f9fb15c10675d%7C0%7C0%7C638730780594371191%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata5Cv%2BzCKjf51kFy%2F8L8lCl0nUX12mEudgYA4CAC80ecx8%3D&reserved50” https://doi.org/10.1053/j.gastro.2019.12.001).
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