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Comparative Study
. 2025 Aug;32(8):1025-1032.
doi: 10.1111/iju.70090. Epub 2025 May 10.

Penile Cancer: Differences Between Patients Over and Under the Age of 75 Years

Yoji Murakami  1 , Takahiro Yamaguchi  2 , Masato Goya  3 , Katsuyoshi Higashijima  4 , Shohei Tobu  5 , Ryuta Sato  6 , Shuichi Tatarano  7 , Shoichiro Mukai  8 , Kei-Ichiro Uemura  9 , Katsunori Tatsugami  10 , Kazuna Tsubouchi  11 , Yohei Shida  12 , Tatsu Ishii  13 , Hideki Sakai  14 , Hirofumi Matsuoka  15   16 , Nobuhiro Haga  16 , Masatoshi Eto  17 , Tsukasa Igawa  9 , Toshiyuki Kamoto  8 , Hideki Enokida  7 , Toshitaka Shin  18 , Mitsuru Noguchi  5 , Naohiro Fujimoto  19 , Seiichi Saitoh  20 , Tomomi Kamba  1
Affiliations
Comparative Study

Penile Cancer: Differences Between Patients Over and Under the Age of 75 Years

Yoji Murakami et al. Int J Urol. 2025 Aug.

Abstract

Objectives: We aimed to evaluate differences in patient characteristics, treatment, and cancer-specific survival between penile cancer patients aged 75 years or older and those younger than 75 years.

Methods: One hundred ninety-six patients with penile cancer who were treated in 12 hospitals in the Kyushu-Okinawa region from 2009 to 2020 were retrospectively analyzed.

Results: The older (age ≥ 75 years) and younger (age < 75 years) groups comprised 80 and 116 patients, respectively. Among all patients with clinical stage 3 disease and those with stage 3A alone, cancer-specific survival was significantly worse in the older group. Patients in the older group exhibited worse Eastern Cooperative Oncology Group Performance Status scores, lower albumin concentrations, and higher neutrophil-to-lymphocyte ratios. Treatment intensity was lower in the older patients, but the findings were not significant: partial penile resection was predominant in the older group, while patients in the younger group more frequently underwent total penile resection. In addition, pelvic lymph node dissection was less frequently performed in the older group.

Conclusions: Among patients with clinical stage 3 penile cancer, cancer-specific survival was worse in those aged 75 years or older. Worse Eastern Cooperative Oncology Group Performance Status scores and less aggressive treatment in the older group may have been contributing factors.

Keywords: cancer‐specific survival; elderly patient; outcomes; penile cancer; treatment selection.

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References

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