Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Apr 16;26(4):26662.
doi: 10.31083/RCM26662. eCollection 2025 Apr.

'One Stop' Therapy has a Satisfying Performance on AF Patients with Interatrial Communication: Evidence from Pooled Clinical Experience

Zhi-Yuan Zhang  1 , Feng Li  1 , Chi Geng  1 , Yu-Qi Chen  1 , Si-Liang Peng  1 , Yao-Ting Zhang  1 , You Zhang  1 , Xiao-Song Gu  1 , Hui Li  1
Affiliations

'One Stop' Therapy has a Satisfying Performance on AF Patients with Interatrial Communication: Evidence from Pooled Clinical Experience

Zhi-Yuan Zhang et al. Rev Cardiovasc Med. .

Abstract

Background: Left atrial appendage closure (LAAC) has been reported to be a viable alternative to prevent thromboembolic events for atrial fibrillation (AF) patients. Interatrial communication closure, such as atrial septal defect (ASD) and patent foramen ovale (PFO) closure could significantly decrease the occurrence of stroke. For AF patients with interatrial communication, the success rate as well as the long-term outcomes of 'One stop' closure remain elusive.

Methods: Studies were systematically screened using online databases (including PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI) database, and WanFang database) from their establishment to 1st August 2024. We utilized a fixed-effect model to synthesize the success rate and the long-term outcomes. Subgroup analysis was performed to identify the potential confounders.

Results: A total of 7 studies comprising 156 patients were included. ASD/PFO closure combined with LAAC showed a high degree of feasibility, with a success rate of 1.00 (95% CI: 0.99, 1.00; p < 0.001). Meanwhile, 'One stop' ASD/PFO closure combined with LAAC exhibited a high long-term safety and a low occurrence of complications. Moreover, subgroup analysis revealed that the bleeding event occurrence was relatively higher in the male proportion ≥50% subgroup and HAS-BLED score ≥3 subgroup, respectively.

Conclusions: ASD/PFO closure combined with LAAC has a satisfying performance on AF patients with interatrial communication.

The prospero registration: CRD42023462221, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023462221.

Keywords: ASD closure; LAAC; PFO closure; atrial fibrillation; atrial septal defect closure; left atrial appendage closure; patent foramen ovale closure.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The flowchart of the study selection. AF, atrial fibrillation; CNKI, China National Knowledge Infrastructure.
Fig. 2.
Fig. 2.
Success rate of ‘One stop’ ASD/PFO closure combined with LAAC. ASD, atrial septal defect; PFO, patent foramen ovale; LAAC, left atrial appendage closure; ES, effect size.
Fig. 3.
Fig. 3.
Long-term adverse events of ‘One stop’ ASD/PFO closure combined with LAAC. ASD, atrial septal defect; PFO, patent foramen ovale; LAAC, left atrial appendage closure; LAA, left atrial appendage.
Fig. 4.
Fig. 4.
Bleeding events during follow up. ES, effect size.
Fig. 5.
Fig. 5.
Device-related events during follow up. ES, effect size.
Fig. 6.
Fig. 6.
All-cause death during follow-up. ES, effect size.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Rigatelli G, Zuin M. Differences and similarities in interatrial shunts management. European Journal of Internal Medicine . 2024;120:25–28. doi: 10.1016/j.ejim.2023.12.007. - DOI - PubMed
    1. Corno AF, Adebo DA, LaPar DJ, Salazar JD. Modern advances regarding interatrial communication in congenital heart defects. Journal of Cardiac Surgery . 2022;37:350–360. doi: 10.1111/jocs.16166. - DOI - PubMed
    1. Brida M, Chessa M, Celermajer D, Li W, Geva T, Khairy P, et al. Atrial septal defect in adulthood: a new paradigm for congenital heart disease. European Heart Journal . 2022;43:2660–2671. doi: 10.1093/eurheartj/ehab646. - DOI - PubMed
    1. Aoun J, Hatab T, Volpi J, Lin CH. Patent Foramen Ovale and Atrial Septal Defect. Cardiology Clinics . 2024;42:417–431. doi: 10.1016/j.ccl.2024.02.019. - DOI - PubMed
    1. Lee PH, Song JK, Kim JS, Heo R, Lee S, Kim DH, et al. Cryptogenic Stroke and High-Risk Patent Foramen Ovale: The DEFENSE-PFO Trial. Journal of the American College of Cardiology . 2018;71:2335–2342. doi: 10.1016/j.jacc.2018.02.046. - DOI - PubMed

Publication types

LinkOut - more resources