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Case Reports
. 2025 Apr 9;17(4):e81981.
doi: 10.7759/cureus.81981. eCollection 2025 Apr.

Mandibular Odontogenic Fibromyxoma: A Case Report of Clinical and Radiographic Presentations

Sara Boukssim  1 , Loubna Amminou  1 , Nadia Cherradi  2 , Hafsa El Ouazzani  2 , Bassima Chami  1
Affiliations
Case Reports

Mandibular Odontogenic Fibromyxoma: A Case Report of Clinical and Radiographic Presentations

Sara Boukssim et al. Cureus. .

Abstract

Odontogenic fibromyxoma (OFM) is an uncommon benign neoplasm originating from the odontogenic ectomesenchyme. It exhibits a slow-growing yet locally aggressive behavior, most frequently presenting in young adults, although it can occur at any age and shows no significant gender predilection. Despite its clinical relevance, current research provides limited information regarding the risk factors, causative agents, and molecular pathways that contribute to its development and aggressive behavior. We present a case of OFM located in the mandible of a 38-year-old African male who reported a painless swelling in the right mandible extending from the first premolar to the second premolar. The clinical examination revealed a limited, firm, painless vestibular swelling in the region of teeth 44 and 45. The affected teeth exhibited normal vitality and physiological mobility. Radiographic imaging demonstrated a multilocular radiolucency with a "soap bubble" appearance, without evidence of root resorption. Histopathological analysis confirmed the diagnosis of odontogenic fibromyxoma, showing a proliferation of fibroblasts and myofibroblasts within a loose, myxomatous stroma rich in acid mucopolysaccharides, with scattered stellate cells displaying minimal pleomorphism. This case underscores the importance of a comprehensive diagnostic approach that integrates clinical, radiological, and histopathological findings to accurately identify OFM and distinguish it from other similar jaw lesions. Although conservative treatments such as enucleation with curettage offer notable benefits, the ideal surgical approach and follow-up protocol remain subjects of ongoing investigation. A more profound understanding of OFM's underlying pathogenesis could lead to improved treatment outcomes and guide future research on targeted therapeutic strategies.

Keywords: benign jaw lesion; mandible; myxofibroma; odontogenic fibromyxoma; odontology.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Intraoral view revealing a well-defined vestibular swelling covered with normal mucosa
Figure 2
Figure 2. Orthopantomographic examination revealing a well-defined multilocular periapical lesion extending from tooth 44 to tooth 46
Figure 3
Figure 3. Macroscopic appearance of the OFM
OFM: odontogenic fibromyxoma
Figure 4
Figure 4. Histological aspect of the lesion showing spindle-shaped or stellate tumor cells, with no atypia and no mitotic figures (HE×40)
HE×40: hematoxylin and eosin at 40× magnification
Figure 5
Figure 5. Microphotograph of an odontogenic myxoma, showing a benign tumor proliferation with low cellular density, developing within an abundant myxoid stroma (HE×10)
HE×10: hematoxylin and eosin at 10× magnification
See this image and copyright information in PMC

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