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. 2025 Mar 27;7(5):365-371.
doi: 10.1253/circrep.CR-24-0139. eCollection 2025 May 9.

Early Changes in Left Ventricular Myocardial Mechanics After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis

Takeru Ikenaga  1 , Yuta Kato  1 , Yuto Kawahira  1 , Midori Miyazaki  1   2 , Tetsuo Hirata  1 , Hiromitsu Teratani  3 , Go Kuwahara  3 , Makoto Sugihara  1 , Hideichi Wada  3 , Masahiro Ogawa  1   2 , Shin-Ichiro Miura  1
Affiliations

Early Changes in Left Ventricular Myocardial Mechanics After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis

Takeru Ikenaga et al. Circ Rep. .

Abstract

Background: Transcatheter aortic valve replacement (TAVR) improves left ventricular (LV) deformation by aortic stenosis (AS). However, the early effects of TAVR on LV mechanics as assessed by echocardiography have not been fully elucidated.

Methods and results: Between 2021 and 2024, we included 81 patients who underwent transfemoral TAVR for severe AS. We used the natural logarithm of B-type natriuretic peptide (lnBNP) 1 week after TAVR as an indicator of the early effects on LV mechanics. To determine the association with echocardiographic parameters (LV ejection fraction [LVEF], global longitudinal strain [GLS], E/e', and Tei index) and postprocedural lnBNP, we used regression models while adjusting for covariates. There were no significant differences in LVEF, GLS or E/e' between before and after TAVR, but the postprocedural Tei index was significantly higher than the preprocedural Tei index (0.40 vs. 0.26, P<0.01). In a univariate linear regression, the preprocedural LVEF (β=-0.28, P=0.01), GLS (β=-0.24, P=0.04), E/e' (β=0.36, P<0.01), and Tei index (β=0.27, P=0.02) correlated with postprocedural lnBNP. Regarding the postprocedural parameters, GLS (β=-0.27, P=0.02) and E/e' (β=0.36, P<0.01) also correlated with postprocedural lnBNP, but the LVEF and Tei index did not. After adjustment for covariates, these correlations remained significant.

Conclusions: Preprocedural echocardiographic parameters reflecting LV function correlated with BNP after TAVR, but the utility of postprocedural parameters may depend on preprocedural LV function or perioperative factors.

Keywords: Aortic stenosis; Echocardiography; Tei index; Transcatheter aortic valve replacement.

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Conflict of interest statement

None of the authors have conflicts of interest to disclose. S.M. is a member of the Editorial Boards of Circulation Journal / Circulation Reports.

Figures

Figure 1.
Figure 1.
Echocardiographic parameters related to left ventricular function. (A) LVEF, (B) GLS, (C) E/e′, and (D) Tei index. ET, ejection time; GLS, global longitudinal strain; ICT, isovolumic contraction time; IRT, isovolumic relaxation time; LVEF, left ventricular ejection fraction.
Figure 2.
Figure 2.
Comparison of pre- and postprocedural echocardiographic parameters related to left ventricular function. GLS, global longitudinal strain; LVEF, left ventricular ejection fraction.
See this image and copyright information in PMC

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References

    1. Spears J, Al-Saiegh Y, Goldberg D, Manthey S, Goldberg S.. TAVR: A review of current practices and considerations in low-risk patients. J Interv Cardiol 2020; 1: 2582938, doi:10.1155/2020/2582938. - PMC - PubMed
    1. Khan SU, Riaz H, Khan MU, Zarak MS, Khan MZ, Khan MS, et al.. Meta-analysis of temporal and surgical risk dependent associations with outcomes after transcatheter versus surgical aortic valve implantation. Am J Cardiol 2019; 124: 1608–1614, doi:10.1016/j.amjcard.2019.07.066. - PMC - PubMed
    1. Forrest JK, Deeb GM, Yakubov SJ, Gada H, Mumtaz MA, RamLawi B, et al.. 3-year outcomes after transcatheter or surgical aortic valve replacement in low-risk patients with aortic stenosis. J Am Coll Cardiol 2023; 81: 1663–1674, doi:10.1016/j.jacc.2023.02.017. - PubMed
    1. Mack MJ, Leon MB, Thourani VH, Pibarot P, Hahn RT, Genereux P, et al.. Transcatheter aortic-valve replacement in low-risk patients at five years. N Engl J Med 2023; 389: 1949–1960, doi:10.1056/NEJMoa2307447. - PubMed
    1. Delgado V, Tops LF, van Bommel RJ, van der Kley F, Marsan NA, Klautz RJ, et al.. Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement. Eur Heart J 2009; 30: 3037–3047, doi:10.1093/eurheartj/ehp351. - PubMed