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. 2024 Mar 21;4(3):100954.
doi: 10.1016/j.checat.2024.100954.

Enantioselective synthesis of axially chiral P-containing allenes for allenyl chirality

Guangshou Feng  1 , Qiu Wang  1
Affiliations

Enantioselective synthesis of axially chiral P-containing allenes for allenyl chirality

Guangshou Feng et al. Chem Catal. .

Abstract

In this issue of Chem Catalysis, Wang J. and co-workers have established an efficient and practical route to construct versatile di-, tri-, and tetra-substituted phosphoryl allenes via a nickel-catalyzed propargylic substitution reaction, offering a powerful tool for the assembly of axially chiral phosphorus-containing allenes.

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Conflict of interest statement

DECLARATION OF INTERESTS The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. J. Wang’s approach to construct axially chiral phosphorus-containing allenes through nickel-catalyzed propargylic substitution
(A) Ni-catalyzed propargylic substitution achieved by diverse phosphorous nucleophiles. (B) Representative multi-substituted allene products from a broad range of phosphorous nucleophiles and functionally propargyl acetates. (C) Control experiments on the catalyst-controlled axial chirality.
See this image and copyright information in PMC

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