Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 Jan 28:60:41-43.
doi: 10.1016/j.jdcr.2024.12.002. eCollection 2025 Jun.

Sweat gland carcinoma with neuroendocrine differentiation of the scalp with elevated serum chromogranin A levels

Elyse C Wyatt  1 , Eric L Wyatt  2 , Robbie L Graham  3
Affiliations
Case Reports

Sweat gland carcinoma with neuroendocrine differentiation of the scalp with elevated serum chromogranin A levels

Elyse C Wyatt et al. JAAD Case Rep. .
No abstract available

Keywords: CgA; LGNECS; SCAND; chromogranin A; low-grade neuroendocrine carcinoma of the skin; sweat gland carcinoma with neuroendocrine differentiation.

PubMed Disclaimer

Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
A, 1.2 cm erythematous scaling plaque. B, Dermoscopy of plaque showing pink and white structureless areas with polymorphous vessels.
Fig 2
Fig 2
A, Punch biopsy histology showing tumor cells within the dermis and superficial subcutis (original magnification ×40). B, Tumor cells in the dermis as cords and nests. The epidermis in uninvolved (original magnification ×100). C, Tumor cells are fairly uniform and round with ample pale to eosinophilic cytoplasm, oval nuclei, mild pleomorphism, and sparse mitosis (original magnification ×200). D, Tumor cells with perineural/intraneural invasion (original magnification ×100). E, Tumor cells positive staining with pan-cytokeratin (original magnification ×100). F, Tumor cells positive staining with synaptophysin (original magnification ×100). G, Tumor cells positive staining with chromogranin (original magnification ×100).
See this image and copyright information in PMC

References

    1. Goto K., Kukita Y., Honma K., et al. Sweat-gland carcinoma with neuroendocrine differentiation (SCAND): a clinicopathologic study of 13 cases with genetic analysis. Mod Pathol. 2022;35(1):33–43. doi: 10.1038/s41379-021-00921-8. - DOI - PubMed
    1. Chen T.Y., Morrison A.O., Susa J., Cockerell C.J. Primary low-grade neuroendocrine carcinoma of the skin: an exceedingly rare entity. J Cutan Pathol. 2017;44(11):978–981. doi: 10.1111/cup.13028. - DOI - PubMed
    1. Al-Janabi S., Kasius J., Jaspars E., Snijders M. Primary cutaneous neuroendocrine tumor of the vulva: a case report. Int J Gynecol Pathol. 2023;42(3):278–281. doi: 10.1097/PGP.0000000000000919. - DOI - PubMed
    1. Krogh S., Bak Nielsen M., Kornerup L.S., Dam G. Case of primary low-grade neuroendocrine carcinoma of the skin. BMJ Case Rep. 2023;16(12) doi: 10.1136/bcr-2023-257569. - DOI - PMC - PubMed
    1. Gkolfinopoulos S., Tsapakidis K., Papadimitriou K., Papamichael D., Kountourakis P. Chromogranin A as a valid marker in oncology: clinical application or false hopes? World J Methodol. 2017;7(1):9–15. doi: 10.5662/wjm.v7.i1.9. - DOI - PMC - PubMed

Publication types

LinkOut - more resources