Dr Sattar reports payments for consultancy or speaker honoraria from Abbott Laboratories, AbbVie, Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Menarini-Ricerche, Novo Nordisk, and Pfizer; and grant support paid to his university from AstraZeneca, Boehringer Ingelheim, Novartis, and Roche Diagnostics. Dr McGuire reports consultancy at Lilly USA, Boehringer Ingelheim, Novo Nordisk, Bayer, Lexicon, Altimmune, Esperion, Intercept Pharmaceuticals, Amgen, Applied Therapeutics, and Neurotronic; and trial leadership at Novo Nordisk, Lilly USA, Pfizer, Boehringer Ingelheim, NewAmsterdam, AstraZeneca, CSL Behring, and Esperion. Dr Kosiborod reports consultancy or advisory board participation for 35Pharma, Alnylam Pharmaceuticals, Amgen, Applied Therapeutics, Arrowhead Pharmaceuticals, AstraZeneca, Bayer, Boehringer Ingelheim, Corcept Therapeutics, Cytokinetics, Dexcom, Eli Lilly, Esperion Therapeutics, Imbria Pharmaceuticals, Janssen, Lexicon Pharmaceuticals, Merck (Diabetes and Cardiovascular), Novo Nordisk, Pharmacosmos, Pfizer, Regeneron, scPharmaceuticals, Sanofi, Structure Therapeutics, Vifor Pharma, and Youngene Therapeutics; research grants form AstraZeneca, Boehringer Ingelheim, and Pfizer; stock options in Artera Health and Saghmos Therapeutics; honoraria from AstraZeneca, Boehringer Ingelheim, and Novo Nordisk; and other research support (data analytic center fees) from AstraZeneca and Vifor Pharma. Dr Lee has received research grants through his institution, the University of Glasgow, from AstraZeneca, Boehringer Ingelheim, and Roche Diagnostics; and is a member of a trial steering committee for Cytokinetics and a clinical endpoints committee for Bayer. Dr Welsh reports grant income from Roche Diagnostics, AstraZeneca, Boehringer Ingelheim, and Novartis; and speaker fees from Novo Nordisk and Raisio outside the submitted work. Dr Pearson has received honoraria from Novo Nordisk, Lilly, and Illumina. Dr N. Pavo has no conflicts to declare. Dr Hülsmann reports fees for consulting and lecturing and scientific support from Roche Diagnostics. Drs Weerakkody, Wiese, Duffin, Wilson, and I. Pavo are employees of and shareholders in Eli Lilly and Company, Indianapolis, IN.