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Review
. 2025 May 9;104(19):e42273.
doi: 10.1097/MD.0000000000042273.

Research progress of radiation esophagitis: A narrative review

Qiang Wu  1   2 , Qiuxia Li  3 , Ruidan Zhang  2 , Yongbin Cui  2 , Jingmin Zou  2 , Jianbo Zhang  2 , Changsheng Ma  2 , Dali Han  2 , Yiru Peng  2
Affiliations
Review

Research progress of radiation esophagitis: A narrative review

Qiang Wu et al. Medicine (Baltimore). .

Abstract

Radiation esophagitis (RE) is an adverse reaction to radiotherapy for thoracic malignancies and a major factor limiting the dosage for thoracic tumors. In cases of RE, mild conditions may involve only discomfort in the throat, severe cases can present with intense pain and significant difficulty swallowing, and may lead to interruptions in radiation therapy, affecting the treatment outcome. However, much of the current research focuses on how to diagnose and treat the disease and needs to address the prevention of RE. In this review, several online databases, including PubMed, Web of Science, Google Scholar, the China National Knowledge Infrastructure, and the Chinese Medical Journal Database, were searched to collect relevant published studies. This review provides updated information on the pathogenesis, diagnosis, risk factors, development of predictive models, prevention, and treatment of RE, aiming to serve as a reference for its diagnosis, treatment, and prevention.

Keywords: prediction model; prevention and treatment; radiation esophagitis; risk factors.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Drishya S, Dhanisha SS, Raghukumar P, Guruvayoorappan C. Amomum subulatum fruits protect against radiation-induced esophagitis by regulating antioxidant status and inflammatory responses. Food Res Int. 2023;174(Pt 1):113582. - PubMed
    1. Marin FS, Hallit R, Coriat R, Chaussade S, Prat F, Barret M. Successful treatment of hemorrhagic radiation esophagitis with radiofrequency ablation. Endoscopy. 2022;54:E830–1. - PMC - PubMed
    1. Lin MQ, Wu YH, Yang J, et al. Gut microbiota characteristics are associated with severity of acute radiation-induced esophagitis. Front Microbiol. 2022;13:883650. - PMC - PubMed
    1. Alam SR, Zhang P, Zhang SY, et al. Early prediction of acute esophagitis for adaptive radiation therapy. Int J Radiat Oncol Biol Phys. 2021;110:883–92. - PMC - PubMed
    1. Bütof R, Löck S, Soliman M, et al. Dose-volume predictors of early esophageal toxicity in non-small cell lung cancer patients treated with accelerated-hyperfractionated radiotherapy. Radiother Oncol. 2020;143:44–50. - PubMed

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