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. 1977 Mar 23;52(1):35-40.
doi: 10.1007/BF00426597.

Evidence for a probenecid-sensitive transport system of acid monoamine metabolites from the spinal subarachnoid space

F W Van der Poel, H M Van Praag, J Korf

Evidence for a probenecid-sensitive transport system of acid monoamine metabolites from the spinal subarachnoid space

F W Van der Poel et al. Psychopharmacology (Berl). .

Abstract

The location of probenecid-sensitive elimination mechanisms of monoamine metabolites from the cerebrospinal fluid of the cat was determined with ventriculo-cisternal or ventriculo-lumbar perfusion techniques. These techniques were described in detail. Levels of endogenous homovanillic acid and 5-hydroxyindoleacetic acid were assayed in the perfusate. Probenecid administration induced the most marked increase of the levels of the monoamine metabolites in the ventriculo-lumbar perfusates. It was concluded that probenecid blocked the transport of both metabolites from the spinal subarachnoid space.

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