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. 2025 May;15(5):e70533.
doi: 10.1002/brb3.70533.

Mediating Role of Depression Severity in the Relationship Between Childhood Trauma and Non-Suicidal Self-Injury Among Adolescents With Mood Disorders

Jianbing Li  1 , Jiaqi Wang  2 , Changhe Fan  1
Affiliations

Mediating Role of Depression Severity in the Relationship Between Childhood Trauma and Non-Suicidal Self-Injury Among Adolescents With Mood Disorders

Jianbing Li et al. Brain Behav. 2025 May.

Abstract

Objective: Non-suicidal self-injury (NSSI) frequently co-occurs with childhood trauma (CT) and depression; however, their interplay and underlying mechanisms are not fully understood. This article explores the nuanced relationships between these factors and their impact on NSSI, offering practical insights for the prevention and intervention of childhood post-traumatic depression progression and NSSI among adolescents.

Methods: The present study leveraged the Childhood Trauma Questionnaire (CTQ), the Adolescent Non-suicidal Self-injury Assessment Questionnaire (ANSAQ), and the Hamilton Rating Scale for Depression (HAMD) to assess a cohort of 361 individuals with mood disorders. The study design was cross-sectional, and a convenience sampling method was utilized. The mediation effect was tested using the Process stepwise regression method, and the significance of the mediation effect was assessed through Bootstrap analysis.

Results: Among 361 adolescents with mood disorders, 232 (64.3%) exhibited NSSI behaviors. Analyses revealed that CT was directly associated with NSSI (β = 0.312, p < 0.001) and indirectly associated through mediation pathways (β = 0.256, p < 0.001). CT also showed direct association with depression severity (β = 0.400, p < 0.001). Depression severity was significantly associated with NSSI (β = 0.184, p = 0.042), suggesting a partial mediating role of depression severity in this relationship.

Conclusions: CT shows a significant association with NSSI among adolescents with mood disorders, with depression severity serving as a partial mediator in this relationship. Active coping strategies targeting depressive symptoms in individuals with a history of CT may help reduce NSSI behaviors.

Keywords: adolescents | childhood trauma (CT) | depression | non‐suicidal self‐injury (NSSI).

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
The role of depression as a mediator in the relationship between childhood trauma and non‐suicidal self‐injury. *p < 0.05; **p < 0.01.
See this image and copyright information in PMC

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References

    1. Afifi, T. O. , Enns M. W., Cox B. J., Asmundson G. J., Stein M. B., and Sareen J.. 2008. “Population Attributable Fractions of Psychiatric Disorders and Suicide Ideation and Attempts Associated With Adverse Childhood Experiences.” American Journal of Public Health 98, no. 5: 946–952. - PMC - PubMed
    1. Bae, Y. , Seong Y., Kim S. H., and Kim S.. 2020. “Clinical Characteristics of Non‐Suicidal Self‐Injury and Suicide Attempts Among Psychiatric Patients in Korea: A Retrospective Chart Review.” Psychiatry Investigation 17, no. 4: 320–330. - PMC - PubMed
    1. Bernstein, D. P. , Stein J. A., Newcomb M. D., et al. 2003. “Development and Validation of a Brief Screening Version of the Childhood Trauma Questionnaire.” Child Abuse & Neglect 27, no. 2: 169–190. - PubMed
    1. Briere, J. , and Gil E.. 1998. “Self‐Mutilation in Clinical and General Population Samples: Prevalence, Correlates, and Functions.” American Journal of Orthopsychiatry 68, no. 4: 609–620. - PubMed
    1. Briggs, S. , Netuveli G., Gould N., et al. 2019. “The Effectiveness of Psychoanalytic/Psychodynamic Psychotherapy for Reducing Suicide Attempts and Self‐Harm: Systematic Review and Meta‐Analysis.” British Journal of Psychiatry 214, no. 6: 320–328. - PubMed

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