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. 1985 Jul 1;39(1):29-42.
doi: 10.1016/0049-3848(85)90119-7.

Platelet thrombospondin haemagglutinin activity is due to aggregate formation

W J Booth, P A Castaldi, M C Berndt

Platelet thrombospondin haemagglutinin activity is due to aggregate formation

W J Booth et al. Thromb Res. .

Abstract

Thrombospondin released from human blood platelets by thrombin activation formed high molecular weight aggregates which co-eluted with haemagglutinin activity on Sepharose 4B gel filtration. Thrombospondin aggregation was mediated by intermolecular disulphide bridges. The aggregates consisted of a series of oligomers ranging from a dimer to polymeric forms with Mr congruent to 40 X 10(6). Native monomeric thrombospondin obtained by a modified procedure was deficient in haemagglutination activity but inhibited haemagglutination induced by aggregated thrombospondin.

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