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. 2025 Apr 28:6:1452114.
doi: 10.3389/fgwh.2025.1452114. eCollection 2025.

Epidemiology of second trimester induced abortion in Ethiopia: a systematic review and meta-analysis

Mesfin Abebe  1 , Tsion Mulat Tebeje  2 , Nebiha Yimer  1 , Tesfaye Temesgen  1 , Getnet Melaku  1 , Habtamu Endashaw Hareru  2
Affiliations

Epidemiology of second trimester induced abortion in Ethiopia: a systematic review and meta-analysis

Mesfin Abebe et al. Front Glob Womens Health. .

Abstract

Background: Second-trimester induced abortion refers to the termination of a pregnancy occurring between 13 and 28 weeks of gestation in Africa. These abortions are particularly concerning due to the heightened risk of complications and maternal mortality. In Ethiopia, there is a lack of nationally representative data regarding the magnitude and associated factors of second-trimester induced abortions. This systematic review and meta-analysis aimed to ascertain the pooled magnitude and identify the factors associated with second-trimester induced abortions in Ethiopia.

Methods: The PRISMA guidelines were used to review and report this study. A systematic literature search was conducted to identify relevant articles from online databases, including PubMed/MEDLINE, Web of Science, Google Scholar, and Ethiopian University online repositories. Data were extracted using an Excel data extraction format, and analysis was performed using Stata version 17. A meta-analysis was conducted using a random-effects model, and subgroup analysis was performed based on the year of publication and sample size to identify the source of heterogeneity. To determine publication bias, a funnel plot, and Egger's regression test were conducted.

Results: In this review, a total of ten articles encompassing 4,466 participants were analyzed. The pooled prevalence of second-trimester induced abortion in Ethiopia was found to be 29.10% (95% CI: 19.96-38.24; I² = 97.84, P < 0.000). Delay in confirming pregnancy (POR = 4.33, 95% CI: 2.25, 8.32), nature of the menstrual cycle (POR = 0.32, 95% CI: 0.18, 0.56), residence (POR = 0.38, 95% CI: 0.30, 0.49), and pregnancy intention (POR = 0.28, 95% CI: 0.18, 0.42) were significantly associated with second-trimester induced abortion.

Conclusions: The magnitude of induced second-trimester abortions in Ethiopia is significantly higher than global data. This meta-analysis identifies factors associated with second-trimester abortions, including delayed pregnancy confirmation, irregular menstrual cycles, rural residency, and unplanned pregnancies. The findings highlight the urgent need for targeted interventions to address these factors and decrease the incidence of second-trimester abortions. Encouraging early pregnancy testing and confirmation to reduce delays, raising awareness about the importance of regular menstrual cycles and seeking medical advice for irregularities, improving healthcare services in rural areas to reduce disparities, and strengthening family planning and counseling services can help mitigate unplanned pregnancies and induced abortions.

Systematic review registration: PROSPERO (CRD42022383559).

Keywords: Ethiopia; epidemiology; meta-analysis; second trimester induced abortion; systematic review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram of the study.
Figure 2
Figure 2
Forest plot of pooled magnitude of second-trimester induced abortion in Ethiopia, 2024.
Figure 3
Figure 3
Sensitivity analysis for the magnitude of second-trimester induced abortion in Ethiopia, 2024.
Figure 4
Figure 4
Funnel plot showing publication bias for the magnitude of second-trimester induced abortion studies in Ethiopia, 2024.
Figure 5
Figure 5
Funnel plots displaying the findings of trim-and-fill analysis for the magnitude of second-trimester induced abortion in Ethiopia, 2024.
See this image and copyright information in PMC

References

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