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. 2025 May 12;43(5):810-812.
doi: 10.1016/j.ccell.2025.04.008.

Stromal barriers to the abscopal effect

Tian V Tian  1 , Silvia Affò  2
Affiliations

Stromal barriers to the abscopal effect

Tian V Tian et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Zhang et al. reveal that PAI-1-induced SFRP2high cancer-associated fibroblasts reduce the abscopal effect of radioimmunotherapy. Targeting PAI-1 or SFRP2 enhances T cell recruitment and prevents the formation of an immunosuppressive perivascular niche, improving radioimmunotherapy's abscopal effect.

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Conflict of interest statement

Declaration of interests T.V.T. receives research grants from AstraZeneca, LOXO Oncology, Servier, Alentis, and Incyte and speaker honoraria from AstraZeneca, Incyte, and Jazz Pharmaceuticals, which are irrelevant to the current study.

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