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. 2025 May 13;15(1):16624.
doi: 10.1038/s41598-025-00629-8.

Effects of ulinastatin on therapeutic outcomes and inflammatory markers in pediatric septic shock patients

Shan Gao #  1 , Siman Cheng #  2 , Qunwei Zhang  1 , Zhizhong Cheng  1 , Le Chen  1 , Zhihong Ren  1 , Yufen Jiang  1 , Wanlong Yin  1 , Pan Du  1 , Shan Gao  1 , Kunlun Zhan  1 , Liu Dai  1 , Chengjiao Huang  3
Affiliations

Effects of ulinastatin on therapeutic outcomes and inflammatory markers in pediatric septic shock patients

Shan Gao et al. Sci Rep. .

Abstract

This study aims to investigate the effects of ulinastatin on therapeutic outcomes and inflammatory markers in children with septic shock. This study selected 117 children with septic shock admitted to our hospital from April 2023 to April 2024. Among them, 7 children had comorbidities, 3 dropped out during the research process, 5 did not continue to participate in the study due to other reasons, and 4 explicitly refused to participate. After screening and excluding the above - mentioned cases, A total of 98 children were allotted to experimental group (ulinastatin combined with routine antishock therapy, n = 49) and control group (routine antishock therapy, n = 49) using stratified random method. The therapeutic effects and levels of inflammatory markers were assessed before and after treatment using a double antibody sandwich ELISA. The outcome was significantly better in the experimental group compared to controls (P < 0.05). Prior to treatment, there were no significant differences in the levels of CD64, procalcitonin (PCT), C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), and serum α-hydroxybutyrate dehydrogenase between the two groups (all P > 0.05). After 7 days of treatment, the experimental group exhibited significantly lower levels of CD64, PCT, C-reactive protein, NLR, and serum α-hydroxybutyrate dehydrogenase compared to the control group (all P < 0.001). Ulinastatin enhances the therapeutic efficacy in children with septic shock by reducing levels of associated inflammatory markers and promoting recovery.

Keywords: Inflammatory indicators; Pediatric patients; Septic shock; Therapeutic effect; Ulinastatin.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee of Huanggang Central Hospital of Yangtze University, and the study was performed in accordance with the Helsinki II declaration. Informed consent was obtained from all the study subjects before enrollment.

Figures

Fig. 1
Fig. 1
Patient inclusion and exclusion flow chart.
Fig. 2
Fig. 2
Comparison of after treatment laboratory indexes between the two groups.
See this image and copyright information in PMC

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