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. 1977 Apr 29;196(4289):538-40.
doi: 10.1126/science.403608.

Antileukemia activity in the Osillatoriaceae: isolation of Debromoaplysiatoxin from Lyngbya

J S Mynderse, R E Moore, M Kashiwagi, T R Norton

Antileukemia activity in the Osillatoriaceae: isolation of Debromoaplysiatoxin from Lyngbya

J S Mynderse et al. Science. .

Abstract

Chloroform extracts of several seaweeds, of the family Oscillatoriaceae, from Enewetak Atoll, Marshall Islands, display activity against P-388 lymphocytic mouse leukemia. A P-388 active compound, debromoaplysiatoxin, has been isolated from Lyngbya gracilis and characterized. This compound also has dermonecrotic activity and may be the dermatitis-producing substance in L. majuscula, the causative agent of "swimmers' itch" outbreaks in Hawaiian waters.

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