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Review
. 2025 Apr 23;17(9):1403.
doi: 10.3390/cancers17091403.

Current Treatment of Uveal Melanoma

Katie Hanratty  1   2 , Gráinne Finegan  1   2 , Keith D Rochfort  1   3 , Susan Kennedy  2   3
Affiliations
Review

Current Treatment of Uveal Melanoma

Katie Hanratty et al. Cancers (Basel). .

Abstract

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults worldwide [...].

Keywords: CTLA-4; PD-1; PD-L1; TMB; immunotherapy; metastasis; uveal; uveal melanoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
(A) Diagram of the eye, illustrating the three possible sites of UM development. (B) Macroscopic cross-section of an enucleated eye, highlighting variegated UM tumour growth and a detached retinal rim [15].
Figure 2
Figure 2
(A) CTLA-4 inhibitor mechanism of action (MOA). (B) PD-1 inhibitor MOA. (C) PD-L1 inhibitor MOA. (D) BiTE MOA [58].
Figure 3
Figure 3
Mechanism of action of Tebentafusp. Created in BioRender [74].
See this image and copyright information in PMC

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References

    1. Krantz B.A., Dave N., Komatsubara K.M., Marr B.P., Carvajal R.D. Uveal melanoma: Epidemiology, etiology, and treatment of primary disease. Clin. Ophthalmol. 2017;11:279–289. doi: 10.2147/OPTH.S89591. - DOI - PMC - PubMed
    1. Baily C., O’Neill V., Dunne M., Cunningham M., Gullo G., Kennedy S., Walsh P.M., Deady S., Horgan N. Uveal Melanoma in Ireland. Ocul. Oncol. Pathol. 2019;5:195–204. doi: 10.1159/000492391. - DOI - PMC - PubMed
    1. Gallenga C.E., Franco E., Adamo G.G., Violanti S.S., Tassinari P., Tognon M., Perri P. Genetic Basis and Molecular Mechanisms of Uveal Melanoma Metastasis: A Focus on Prognosis. Front. Oncol. 2022;12:828112. doi: 10.3389/fonc.2022.828112. - DOI - PMC - PubMed
    1. Mahendraraj K., Lau C.S., Lee I., Chamberlain R.S. Trends in incidence, survival, and management of uveal melanoma: A population-based study of 7516 patients. Clin. Ophthalmol. 2016;10:2113–2119. doi: 10.2147/OPTH.S113623. - DOI - PMC - PubMed
    1. Park S.L., Le Marchand L., Wilkens L.R., Kolonel L.N., Henderson B.E., Zhang Z.F., Setiawan V.W. Risk Factors for Malignant Melanoma in White and Non-White/Non–African American Populations. Cancer Prev. Res. 2012;5:423–434. doi: 10.1158/1940-6207.CAPR-11-0460. - DOI - PMC - PubMed

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