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Review
. 2025 Apr 23;17(9):1403.
doi: 10.3390/cancers17091403.

Current Treatment of Uveal Melanoma

Katie Hanratty  1   2 , Gráinne Finegan  1   2 , Keith D Rochfort  1   3 , Susan Kennedy  2   3
Affiliations
Review

Current Treatment of Uveal Melanoma

Katie Hanratty et al. Cancers (Basel). .

Abstract

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults worldwide [...].

Keywords: CTLA-4; PD-1; PD-L1; TMB; immunotherapy; metastasis; uveal; uveal melanoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
(A) Diagram of the eye, illustrating the three possible sites of UM development. (B) Macroscopic cross-section of an enucleated eye, highlighting variegated UM tumour growth and a detached retinal rim [15].
Figure 2
Figure 2
(A) CTLA-4 inhibitor mechanism of action (MOA). (B) PD-1 inhibitor MOA. (C) PD-L1 inhibitor MOA. (D) BiTE MOA [58].
Figure 3
Figure 3
Mechanism of action of Tebentafusp. Created in BioRender [74].
See this image and copyright information in PMC

References

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