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Review
. 2025 May 5;17(9):1569.
doi: 10.3390/cancers17091569.

An Updated Meta-Analysis on Long-Term Outcomes Following Hyperthermic Intraperitoneal Chemotherapy in Advanced Ovarian Cancer

Nadine El Kassis  1   2 , Myriam Jerbaka  1   2 , Rime Abou Chakra  1   2 , Christopher El Hadi  3 , Wissam Arab  4 , Houssein El Hajj  5 , Donal J Brennan  6 , David Atallah  1   2
Affiliations
Review

An Updated Meta-Analysis on Long-Term Outcomes Following Hyperthermic Intraperitoneal Chemotherapy in Advanced Ovarian Cancer

Nadine El Kassis et al. Cancers (Basel). .

Abstract

Ovarian cancer is the leading cause of death among gynecological malignancies [...].

Keywords: cytoreductive surgery; disease-free survival; epithelial ovarian cancer; hyperthermic intraperitoneal chemotherapy; overall survival; progression-free survival.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Study selection and research strategy.
Figure 2
Figure 2
Flowchart illustrating the systematic review and meta-analysis process conducted in this study, adapted from the PRISMA 2020 statement, providing updated guidelines for systematic review reporting. (Source: Page, M.J., McKenzie, J.E., Bossuyt, P.M., Boutron, I., Hoffmann, T.C., Mulrow, C.D., et al. BMJ 2021;372:n71. doi: 10.1136/bmj.n71. [5] For additional details, refer to: http://www.prisma-statement.org/ [4]) accessed on 30 July 2024.
Figure 3
Figure 3
Funnel plots assessing publication bias among the included studies. (Left plot) Funnel plot for OS. (Right plot) Funnel plot for PFS. The vertical line represents the pooled HR effect size, and the diagonal lines indicate the expected 90, 95 and 99% confidence intervals.
Figure 4
Figure 4
Forest plot for the pooled overall survival hazard ratio, featuring primary and recurrent ovarian cancer subgroups [16,17,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35].
Figure 5
Figure 5
Forest plot for the pooled progression-free survival hazard ratio, featuring primary and recurrent ovarian cancer subgroups [16,20,21,22,24,25,27,28,29,32,34,35].
Figure 6
Figure 6
Forest plot of relative risks reported by the studies [17,18,19,20,22,24,25,26,27,28,29,30,33,35].
See this image and copyright information in PMC

References

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    1. PRISMA Statement. [(accessed on 1 May 2024)]. Available online: https://www.prisma-statement.org.
    1. Page M.J., McKenzie J.E., Bossuyt P.M., Boutron I., Hoffmann T.C., Mulrow C.D., Shamseer L., Tetzlaff J.M., Akl E.A., Brennan S.E., et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71. - DOI - PMC - PubMed

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