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Review
. 2025 Apr 28;26(9):4188.
doi: 10.3390/ijms26094188.

Unlocking the Pharmacological Potential of Myricetin Against Various Pathogenesis

Saleh A Almatroodi  1 , Arshad Husain Rahmani  1
Affiliations
Review

Unlocking the Pharmacological Potential of Myricetin Against Various Pathogenesis

Saleh A Almatroodi et al. Int J Mol Sci. .

Abstract

Myricetin is a natural flavonoid with powerful antioxidant and anti-inflammatory potential commonly found in vegetables, fruits, nuts, and tea. The vital role of this flavonoid in the prevention and treatment of various diseases is evidenced by its ability to reduce inflammation and oxidative stress, maintain tissue architecture, and modulate cell signaling pathways. Thus, this review summarizes recent evidence on myricetin, focusing precisely on its mechanisms of action in various pathogenesis, including obesity, diabetes mellitus, arthritis, osteoporosis, liver, neuro, cardio, and reproductive system-associated pathogenesis. Moreover, it has been revealed that myricetin exhibits anti-microbial properties due to obstructive virulence factors, preventing biofilm formation and disrupting membrane integrity. Additionally, synergistic potential with other drugs and the role of myricetin-based nanoformulations in different diseases are properly discussed. This review seeks to increase the understanding of myricetin's pharmacological potential in various diseases, principally highlighting its effective mechanisms of action. Further wide-ranging research, as well as more randomized and controlled clinical trial studies, should be executed to reconnoiter this compound's therapeutic value, safety, and usefulness against various human pathogenesis.

Keywords: inflammation; myricetin; nanoformulation; oxidative stress; pathogenesis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 8
Figure 8
Antimicrobial potential of myricetin through different mechanisms.
Figure 1
Figure 1
Chemical structure of myricetin (Chemical structure was made using the Chemical Sketch Tool: https://www.rcsb.org/chemical-sketch).
Figure 2
Figure 2
Hepatoprotective potential of myricetin through different mechanisms (the liver image used in the figure is from our lab). The downward-pointing arrow shows downregulation, whereas the upward arrow represents upregulation.
Figure 3
Figure 3
Anti-diabetic, neuroprotective and cardioprotective potential of myricetin through various mechanisms. The downward-pointing arrow shows downregulation, whereas the upward arrow represents upregulation.
Figure 4
Figure 4
Anti-cancerous effects of myricetin via modulation of cell signaling molecules. The downward-pointing arrow shows downregulation, whereas the upward arrow represents upregulation.
Figure 5
Figure 5
The role of myricetin in managing lung pathogenesis through different mechanisms (the lung image used in the figure is from our lab). The downward-pointing arrow shows downregulation.
Figure 6
Figure 6
Role of myricetin in eye disease, bone disease, obesity, and wound healing. The downward-pointing arrow shows downregulation, whereas the upward arrow represents upregulation.
Figure 7
Figure 7
Role of myricetin as renoprotective, anti-arthritis, and in reproductive system. The downward-pointing arrow shows downregulation, whereas the upward arrow represents upregulation.
Figure 9
Figure 9
Myricetin-based nanoformulation and their role in disease management. The downward-pointing arrow shows downregulation, whereas the upward arrow represents upregulation.
See this image and copyright information in PMC

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