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Review
. 2025 May 7;26(9):4448.
doi: 10.3390/ijms26094448.

Altering the Hydrogen Isotopic Composition of the Essential Nutrient Water as a Promising Tool for Therapy: Perspectives and Risks

Nataliya V Yaglova  1 , Sergey S Obernikhin  1 , Ekaterina P Timokhina  1 , Elina S Tsomartova  1   2 , Valentin V Yaglov  1 , Svetlana V Nazimova  1 , Marina Y Ivanova  2 , Elizaveta V Chereshneva  2 , Tatiana A Lomanovskaya  2 , Dibakhan A Tsomartova  2
Affiliations
Review

Altering the Hydrogen Isotopic Composition of the Essential Nutrient Water as a Promising Tool for Therapy: Perspectives and Risks

Nataliya V Yaglova et al. Int J Mol Sci. .

Abstract

Water is a vital nutrient that is needed to maintain almost all biological processes in living organisms. The natural water contains two isotopes of hydrogen-protium and deuterium. Deuterium, the trace component of natural water, significantly changes its physical and chemical properties and biological action. In this review, the authors summarize data on the isotopic effects of deuterium and discuss the possible magnetic effects of isotopes and the molecular basis of the biological effects of deuterium-depleted water. The review also presents new data on the already known and potential use of deuterium-depleted water in medicine (oncology, neurology) and previously unknown new directions of its use (immunological and endocrine disorders, anemia). Based on the analysis of collected data, the authors presented mechanisms of action of deuterium-depleted water in the organism. The authors also identified the least-studied effects of deuterium-depleted water, particularly its influence on morphogenetic processes. The review discloses the perspectives on deuterium-depleted water as a tool for therapy and substantiates the risks of its uncontrolled intake.

Keywords: anemia; deuterium-depleted water; endocrinology; hydrogen; immunology; isotope effect; neurology; oncology; water.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The quaternary organization of the AQP1 [14].
Figure 2
Figure 2
Possible mechanisms of the physiological effects of deuterium-depleted water.
See this image and copyright information in PMC

References

    1. Mosin O., Ignatov I. Biological influence of deuterium on prokaryotic and eukaryotic cells. J. Med. Physiol. Biophys. 2014;1:52–72. doi: 10.13187/EJMB.2014.3.11. - DOI
    1. Mosin O., Ignatov I. Studying the influence of heavy and deuterium depleted types of water on biological objects. J. Med. Physiol. Biophys. 2016;22:35–49.
    1. Urey H.C., Brickwedde F.G., Murphy G.M. A hydrogen isotope of mass 2. Phys. Rev. 1932;39:164–165. doi: 10.1103/PhysRev.39.164. - DOI
    1. Zachleder V., Vítová M., Hlavová M., Moudříková Š., Mojzeš P., Heumann H., Becher J.R., Bišová K. Stable isotope compounds—Production, detection, and application. Biotechnol. Adv. 2018;36:784–797. doi: 10.1016/j.biotechadv.2018.01.010. - DOI - PubMed
    1. Kopf S., Bourriquen F., Li W., Neumann H., Junge K., Beller M. Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules. Chem. Rev. 2022;122:6634–6718. doi: 10.1021/acs.chemrev.1c00795. - DOI - PubMed

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