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Comparative Study
. 2025 May;48(5):e70152.
doi: 10.1002/clc.70152.

Outcomes of Left Atrial Appendage Occlusion in Hispanic/Latino Patients: Insights From the National Inpatient Sample

Mashli Fleurestil  1 , Ayush Mohan  1 , Ian Ergui  1 , Jacklyn Samaha  1 , Rosario Colombo  2 , Raul Mitrani  3 , Eduardo de Marchena  3 , Pedro Villablanca  4 , Jose Wiley  5 , Yiannis S Chatzizisis  3 , Pedro Cox  3
Affiliations
Comparative Study

Outcomes of Left Atrial Appendage Occlusion in Hispanic/Latino Patients: Insights From the National Inpatient Sample

Mashli Fleurestil et al. Clin Cardiol. 2025 May.

Abstract

Background: Left atrial appendage occlusion (LAAO) is an established therapy for stroke prevention in non-valvular atrial fibrillation (NVAF), but outcomes in Hispanic populations remain underexplored.

Objective: The objective of our study was to evaluate the inpatient outcomes of Hispanic patients undergoing LAAO as compared to non-Hispanic white patients.

Methods: We conducted a retrospective cohort study using the National Inpatient Sample (NIS). From 157 434 LAAO hospitalizations identified, 133 517 were non-Hispanic white and 6814 were Hispanic/Latino. The primary outcome was in-hospital mortality.

Results: Unadjusted odds in the Hispanic/Latino group were higher for mortality (OR 1.78, 95% CI 1.18-2.68, p 0.006), stroke (OR 1.64, 95% CI 1.26-2.14, p < 0.001), infectious complications (OR 3.89, 95% CI 3.03-4.99, p < 0.001), major bleeding (OR 1.22, 95% CI 1.11-1.33, p < 0.001), DVT/PE (OR 2.15, 95% CI 1.58-2.93, p < 0.001), and vascular complications (OR 1.81, 95% CI 0.53-0.93, p < 0.001). After adjusting for covariates and comorbidities, Hispanic/Latino patients had still greater odds of mortality (aOR 1.20, 95% CI 0.75-1.92, p 0.445), infectious complications (aOR 3.54, 95% CI 2.62-4.55, p < 0.001), and vascular complications (aOR 1.57, 95% CI 1.22-2.03, p < 0.001). Non-Hispanic white patients had higher adjusted odds of pericardial effusion/tamponade (aOR 0.64, 95% CI 0.52-0.95, p 0.03), while Hispanic/Latino patients also had higher adjusted odds of cardiac arrest (aOR 1.99, 95% CI 1.15-3.42, p 0.46).

Conclusion: Hispanic/Latino patients undergoing LAAO experience higher odds of infectious and vascular complications compared to non-Hispanic white patients. These findings highlight the need to further investigate disparities in procedural outcomes.

Keywords: Hispanic/Latino; LAAO; health disparities; major bleeding; vascular complications; venous thromboembolism.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart detailing the selection of LAAO hospitalizations between 2011 and 2021.
Figure 2
Figure 2
Adjusted in‐hospital outcomes and events in Hispanic/Latin versus White patients hospitalized for LAAO. Values > 1 indicate higher odds in patients Hispanic/Latin patients. LAAO, left atrial appendage occlusion.
Figure 3
Figure 3
Unadjusted odds ratios for outcomes for LAAO hospitalizations. Outcomes reported as 95% confidence intervals. Values > 1 indicate higher odds in patients Hispanic/Latin patients. p value <0.001 was statistically significant.
Figure 4
Figure 4
Adjusted odds ratios for outcomes for LAAO hospitalizations. Adjusted in‐hospital outcomes and events in Hispanic/Latin versus White patients hospitalized for LAAO reported as 95% confidence intervals. Values > 1 indicate higher odds in patients Hispanic/Latin patients.
See this image and copyright information in PMC

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