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Review

IRON OVERLOAD AND CHELATION

John B. Porter  1 , John C. Wood  2 , Thomas D. Coates  3
A.T. Taher  1 , D. Farmakis  2 , J.B. Porter  3 , M.D. Cappellini  4 , K.M. Musallam  5
, editors.
In: Guidelines for the Management of Transfusion-Dependent β-Thalassaemia (TDT) [Internet]. 5th edition. Nicosia, Cyprus: Thalassaemia International Federation; 2025. Chapter 3.
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Review

IRON OVERLOAD AND CHELATION

John B. Porter et al.
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No abstract available

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Conflict of interest statement

JBP reports honoraria from Agios Pharmaceuticals, bluebird bio, Celgene (Bristol Myers Squibb), La Jolla Pharmaceuticals, Protagonism, Silence Therapeutics, and Vifor; and is a consultant for Agios Pharmaceuticals, bluebird bio, and Celgene (Bristol Myers Squibb). JCW reports research funding from the National Heart, Lung, and Blood Institute and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health; research support-in-kind from Philips Healthcare; consultancy for Celgene (Bristol Myers Squibb), WorldCare Clinical, Agios Pharmaceuticals, Pharmacosmos, and Hillhurst; advisory boards for Vifor, Regeneron; and educational lectures for Chiesi and bluebird bio. TDC reports advisory support to Agios Pharmaceuticals, Bristol Myers Squibb, and Chiesi. All competing interests are outside the present work.

References

    1. Kattamis A, Kwiatkowski JL, Aydinok Y Thalassaemia. Lancet . 2022;399(10343):2310–2324. - PubMed
    1. Taher AT, Musallam KM, Cappellini MD beta-Thalassemias. N Engl J Med . 2021;384(8):727–743. - PubMed
    1. Porter JB Iron Through the Prism of Haematology. Br J Haematol . 2020;191(4):587–592. - PubMed
    1. Coates TD Management of iron overload: lessons from transfusion-dependent hemoglobinopathies. Blood . 2024 Online ahead of print. - PubMed
    1. Porter JB, Abeysinghe RD, Marshall L, Hider RC, Singh S Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy. Blood . 1996;88(2):705–713. - PubMed

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