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. 2025 May 15;392(19):1973-1975.
doi: 10.1056/NEJMc2502456.

Longitudinal Changes in Airway Mucus Plugs and FEV1 in COPD

Sofia K Mettler  1 , Pietro Nardelli  1 , Monica Iturrioz Campo  1 , Rubén San José Estépar  1 , Padma P Manapragada  2 , Mostafa Abozeed  2 , Muhammad Usman Aziz  2 , Mohd Zahid  2 , Scott Grumley  2 , Hrudaya P Nath  2 , Andrew Yen  3 , Sushilkumar Sonavane  4 , Christian F Clarenbach  5 , Wei Wang  1 , Carrie L Pistenmaa  1 , George R Washko  1 , Raúl San José Estépar  1 , Michael H Cho  1 , Alejandro A Diaz  1 ; COPDGene Investigators; COPDGene site investigators
Collaborators, Affiliations

Longitudinal Changes in Airway Mucus Plugs and FEV1 in COPD

Sofia K Mettler et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1
(A) Unadjusted post-bronchodilator FEV1 in mL at the baseline and 5-year follow-up visits by mucus plug change category. (B) Estimated marginal means of post-bronchodilator FEV1 (mL/year) changes by mucus plug change category (negative numbers indicate decline). Marginal means are estimated by a multivariable linear regression model adjusting for age, sex, race, BMI, height, pack-years, change in smoking status, baseline FEV1, history of asthma, history of congestive heart failure, CT measures of wall thickness and emphysema and baseline mucus plug score. (C) Estimated marginal means with the same multivariable model, including interaction between mucus plug change and smoking status change. Error bars represent 95% confidence intervals. See Table S5 for complete results.
See this image and copyright information in PMC

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