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. 2025 Aug;72(8):e31790.
doi: 10.1002/pbc.31790. Epub 2025 May 14.

Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives

Kathryn S Sutton  1   2 , Amy L Walz  3 , Alissa Groenendijk  4 , Andrew J Murphy  5 , Luke Pater  6 , Geert O Janssens  4   7 , Jack Brzezinski  8   9 , Elizabeth A Mullen  10 , Filippo Spreafico  11 , Jan Godzinski  12   13 , Justine van der Beek  4   14 , Marc Hwa Wijnen  15 , Marry M van den Heuvel-Eibrink  4   16 , Max Pachl  17   18 , Norbert Graf  19 , Peter F Ehrlich  20 , Rhoikos Furtwangler  21 , Jesper Brok  22 , James Geller  23
Affiliations

Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives

Kathryn S Sutton et al. Pediatr Blood Cancer. 2025 Aug.

Abstract

Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.

Keywords: Wilms tumor; renal; solid; tumors.

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Conflict of interest statement

Conflict of Interest Statement

The authors have no conflicts of interest relevant to this manuscript to disclose.

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