Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2025 Sep;103(6):e364-e373.
doi: 10.1111/aos.17509. Epub 2025 May 15.

Laser prophylaxis for retinal detachment in Stickler syndrome: A systematic review and meta-analysis

David A Camp  1 , Saaquib R Bakhsh  1 , Ali Torkashvand  1 , Nathan R Jensen  2 , Ameay V Naravane  3 , Peter J Belin  3   4 , Polly A Quiram  3   4 , Tsveta Ivanova  5 , Thomas J Wubben  6 , Cagri G Besirli  6 , Brenda L Bohnsack  7 , Michael J Shapiro  8 , Michael P Blair  8   9 , Amir R Hajrasouliha  1
Affiliations
Meta-Analysis

Laser prophylaxis for retinal detachment in Stickler syndrome: A systematic review and meta-analysis

David A Camp et al. Acta Ophthalmol. 2025 Sep.

Abstract

Purpose: To evaluate the effectiveness of laser prophylaxis in preventing retinal detachment (RD) in patients with Stickler syndrome.

Methods: A literature search was performed to identify studies that compared RD rates between eyes that received laser prophylaxis and eyes that received no laser prophylaxis in patients with Stickler syndrome. Data sets from the included studies were pooled and analysed. Individual eyes that presented with RD and eyes without RD with <6 months of follow-up were excluded. The primary outcome was the rate of RD. The study was conducted in accordance with the PRISMA guideline 2020 for systematic reviews.

Results: There were 6 articles included in the meta-analysis, including 400 eyes of 225 patients. RD rate was 6.6% (19 of 289) in eyes with laser compared to 36.0% (40 of 111) in eyes with no laser (p < 0.00001, chi-square) with a mean follow-up interval of 6.3 years for eyes with laser and 4.0 years for eyes with no laser. The pooled risk ratio for retinal detachment after laser prophylaxis was 0.23 (95% CI: 0.13-0.41).

Conclusion: Prophylactic laser therapy was associated with a significantly lower risk of RD in patients with Stickler syndrome compared to no laser prophylaxis.

Keywords: Stickler syndrome; genetic; laser; prophylaxis; retina; retinal detachment.

PubMed Disclaimer

References

REFERENCES

    1. Alexander, P., Fincham, G.S., Brown, S., Collins, D., McNinch, A.M., Poulson, A.V. et al. (2023) Cambridge prophylactic protocol, retinal detachment, and Stickler syndrome. The New England Journal of Medicine, 388, 1337–1339.
    1. Alshahrani, S.T., Ghazi, N.G. & Al‐Rashaed, S. (2016) Rhegmatogenous retinal detachments associated to Stickler syndrome in a tertiary eye care center in Saudi Arabia. Clinical & Experimental Ophthalmology, 10, 1–6.
    1. Ang, A., Poulson, A.V., Goodburn, S.F., Richards, A.J., Scott, J.D. & Snead, M.P. (2008) Retinal detachment and prophylaxis in type 1 Stickler syndrome. Ophthalmology, 115, 164–168.
    1. Boysen, K.B., La Cour, M. & Kessel, L. (2020) Ocular complications and prophylactic strategies in Stickler syndrome: a systematic literature review. Ophthalmic Genetics, 41, 223–234.
    1. Campochiaro, P.A., Gaskin, H.C. & Vinores, S.A. (1987) Retinal Cryopexy stimulates traction retinal detachment formation in the presence of an ocular wound. Archives of Ophthalmology, 105, 1567–1570.

MeSH terms

Supplementary concepts