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Case Reports
. 2025 Apr 30:12:1587988.
doi: 10.3389/fsurg.2025.1587988. eCollection 2025.

Conservative therapy of epidural hematoma with atorvastatin combined with glucocorticoids: cases report and literature review

Chenrui Wu #  1   2   3 , Yu Tian #  3 , Ruichen Zhao #  3 , Runfang Chen  4 , Chuanlin Xu  4 , Jinsheng Huang  4 , Rongcai Jiang  1
Affiliations
Case Reports

Conservative therapy of epidural hematoma with atorvastatin combined with glucocorticoids: cases report and literature review

Chenrui Wu et al. Front Surg. .

Abstract

Epidural hematomas (EDH), typically requiring surgery, may be managed conservatively in select patients. We investigated atorvastatin (10 mg/day) combined with dexamethasone (2.25 mg/day) as conservative therapy in six EDH patients (GCS ≥ 13, volume < 30 ml) post-trauma. All patients recovered fully without surgery, and literatures support conservative care for stable EDH. Our findings suggest this combination therapy may promote hematoma absorption. In conclusion, atorvastatin/dexamethasone shows promise as a non-surgical EDH option, warranting further investigation.

Keywords: atorvastatin; conservative treatment; dexamethasone; epidural hematoma; meningeal lymphatic system.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) Representative patients head CT shows changes in hematoma at admission and after the treatment. (B) Clinical decision diagram for the treatment of EDH patients. (C) The diagram illustrates the pathological anatomy of EDH and SDH. Targeting the dura mater lymphatic vessels may be a potential approach for treating EDH and SDH.
See this image and copyright information in PMC

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