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Randomized Controlled Trial
. 2025 Apr 30:13:1531608.
doi: 10.3389/fpubh.2025.1531608. eCollection 2025.

Health-state utility values and their time to deterioration in informal caregivers of older patients with chronic diseases

Astrid Pozet  1 , Antoine Falcoz  2 , Cécile Roller  3 , Taha Jai  4 , Aurelia Meurisse  2 , Virginie Nerich  5
Affiliations
Randomized Controlled Trial

Health-state utility values and their time to deterioration in informal caregivers of older patients with chronic diseases

Astrid Pozet et al. Front Public Health. .

Abstract

Objectives: This study aimed to assess health state utility values (HSUVs) in caregivers of older patients with chronic diseases receiving or not receiving social worker support.

Methods: This multicentric open-label randomized study assigned caregivers to receive either an informational booklet alone or one accompanied by social worker support. Caregivers completed EQ-5D-3L each semester for 24 months. We reported caregiver HSUVs at baseline and after 6, 12, 18, and 24 months using EQ-5D-3L utility index scores and exploring their time to deterioration (TTD).

Results: Among 179 included caregivers, the percentage reporting some or extreme problems on five EQ-5D-3L dimensions remained almost stable over time with a median EQ-5D-3L utility index score of 0.89 [0.80-1.00] at baseline (n = 177), 0.80 [0.80-0.89] at M6 (n = 125), and 0.80 [0.73-0.91] at M24 (n = 81). Among the respondents, 62% (n = 109) experienced a deterioration in EQ-5D-3L utility index score, with a median TTD of 9.1 months [95%CI 6.2-14.9] in the control group (CG) and 9.5 months [6.3-14.4] in the supportive intervention group (SIG) (HR = 1.06 [0.73-1.54]), p-value = 0.76.

Conclusion: Our study provides a catalog of HSUVs across different caregiver profiles and at various follow-up time points, which can inform future economic evaluations.

Clinical trial registration: ClinicalTrials.gov, NCT02626377.

Keywords: caregiver; economic value; health-state utility value; older patient; social worker support; time to deterioration.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Trial profile (France, 2015–2019). M, month.
Figure 2
Figure 2
Kaplan–Meier estimation of time to deterioration of EQ-5D-3L utility index score. CG, control group; SIG, supportive intervention group; HR, hazard ratio; CI, confidence interval; TTD, time to deterioration.
Figure 3
Figure 3
Kaplan–Meier estimation of time to deterioration of EQ VAS score. CG, control group; SIG, supportive intervention group; HR, hazard ratio; CI, confidence interval; TTD, time to deterioration.
See this image and copyright information in PMC

References

    1. Kaschowitz J, Brandt M. Health effects of informal caregiving across Europe: a longitudinal approach. Soc Sci Med. (2017) 173:72–80. doi: 10.1016/j.socscimed.2016.11.036, PMID: - DOI - PubMed
    1. Le DD, Ibuka Y. Understanding the effects of informal caregiving on health and well-being: heterogeneity and mechanisms. Soc Sci Med. (2023) 317:115630. doi: 10.1016/j.socscimed.2022.115630, PMID: - DOI - PubMed
    1. Schofield D, Shrestha RN, Zeppel MJB, Cunich MM, Tanton R, Veerman JL, et al. . Economic costs of informal care for people with chronic diseases in the community: lost income, extra welfare payments, and reduced taxes in Australia in 2015-2030. Health Soc Care Community. (2019) 27:493–501. doi: 10.1111/hsc.12670, PMID: - DOI - PubMed
    1. BVA, Fondation April. BVA Xsight . (2022). Baromètre des aidants – Avancées et perspectives. Available online at: https://www.bva-xsight.com/sondages/barometre-aidants-bva-fondation-apri...
    1. de Oliveira GR, Neto JF, de Camargo SM, Lucchetti ALG, Espinha DCM, Lucchetti G. Caregiving across the lifespan: comparing caregiver burden, mental health, and quality of life. Psychogeriatrics. (2015) 15:123–32. doi: 10.1111/psyg.12087, PMID: - DOI - PubMed

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