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Review
. 2025 Jun;20(12):1461-1477.
doi: 10.1080/17435889.2025.2504320. Epub 2025 May 15.

Nanomaterial-based scaffolds for bone regeneration with piezoelectric properties

Chandra Sekhar Kathera  1 , Zehra Cobandede  2 , Kaylea Titus  1 , Ibrahim Mohammad  1 , Mustafa Culha  1
Affiliations
Review

Nanomaterial-based scaffolds for bone regeneration with piezoelectric properties

Chandra Sekhar Kathera et al. Nanomedicine (Lond). 2025 Jun.

Abstract

For proper cellular growth, to prepare tissue scaffold mimicking the tissue properties is a significant challenge. Bone is a vital organ supporting the whole human body for its function. The efficiencies in its structure for a variety of reasons should properly be remedied. Bone tissue engineering (BTE) is an emerging field addressing to develop or repair bone tissue for its proper function. The bone is naturally a piezoelectric material and generates electrical stimuli because of mechanical stress. Thus, the use of piezoelectric materials to build bone tissue is of great interest in BTE. Both piezoelectric polymers and nanomaterials (NMs) are investigated for this goal. In this review, we give an overview of the recent advances in piezoelectric NMs to construct piezoelectric scaffolds in BTE.

Keywords: NMs; Piezoelectricity; bone; osteoblast; scaffold; tissue.

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Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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