Abridging the 22-Item Sino-Nasal Outcome Test (SNOT-22) in People With Cystic Fibrosis: Limiting Survey Burden

Haidee Chen¹, Jakob L Fischer¹, Tristan D Tibbe², Ahmad R Sedaghat³, Ethan J Han¹, Jess C Mace⁴, Jeremiah A Alt⁵, Todd E Bodner⁶, Naweed I Chowdhury⁷, Yuqing A Gao⁸, Peter H Hwang⁹, Ashoke Khanwalkar¹⁰, Adam J Kimple¹¹, Jivianne T Lee¹, Douglas A Li¹², Meghan Norris¹¹, Jayakar V Nayak⁹, Cameran Collins¹⁰, Zara M Patel⁹, Katie Phillips³, Katie Poch¹³, Rodney J Schlosser¹⁴, Kristine A Smith⁵, Zachary M Soler¹⁴, Jeffrey D Suh¹, Grant A Turner⁸, Marilene B Wang¹, Anne Getz¹⁰, Ashleigh Halderman¹⁵, Sei Chung¹⁵, Jeremy P Tervo¹⁶, Jonathan B Overdevest¹⁶, Ryan A Cotter³, Milene T Saavedra¹³, Jennifer L Taylor-Cousar^{10

13}, Myung-Shin Sim², Daniel M Beswick¹

Affiliations

¹ Department of Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
² David Geffen School of Medicine, University of California Los Angeles, CTSI, Los Angeles, California, USA.
³ Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
⁴ Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
⁵ Department of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
⁶ Department of Psychology, Portland State University, Portland, Oregon, USA.
⁷ Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
⁸ Department of Pulmonary Medicine, University of California Los Angeles, Los Angeles, California, USA.
⁹ Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.
¹⁰ Department of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
¹¹ Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
¹² Department of Pediatrics Pulmonary Medicine, University of California Los Angeles, Los Angeles, California, USA.
¹³ Department of Medicine, National Jewish Health, Denver, Colorado, USA.
¹⁴ Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
¹⁵ Department of Otolaryngology, University of Texas Southwestern, Dallas, Texas, USA.
¹⁶ Department of Otolaryngology, Columbia University Medical Center, New York, New York, USA.

PMID: 40371719
PMCID: PMC12315476
DOI: 10.1002/alr.23591

Abridging the 22-Item Sino-Nasal Outcome Test (SNOT-22) in People With Cystic Fibrosis: Limiting Survey Burden

Haidee Chen et al. Int Forum Allergy Rhinol. 2025 Aug.

. 2025 Aug;15(8):865-868.

doi: 10.1002/alr.23591. Epub 2025 May 15.

Authors

Affiliations

¹ Department of Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
² David Geffen School of Medicine, University of California Los Angeles, CTSI, Los Angeles, California, USA.
³ Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
⁴ Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
⁵ Department of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
⁶ Department of Psychology, Portland State University, Portland, Oregon, USA.
⁷ Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
⁸ Department of Pulmonary Medicine, University of California Los Angeles, Los Angeles, California, USA.
⁹ Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.
¹⁰ Department of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
¹¹ Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
¹² Department of Pediatrics Pulmonary Medicine, University of California Los Angeles, Los Angeles, California, USA.
¹³ Department of Medicine, National Jewish Health, Denver, Colorado, USA.
¹⁴ Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
¹⁵ Department of Otolaryngology, University of Texas Southwestern, Dallas, Texas, USA.
¹⁶ Department of Otolaryngology, Columbia University Medical Center, New York, New York, USA.

PMID: 40371719
PMCID: PMC12315476
DOI: 10.1002/alr.23591

No abstract available

Keywords: SNOT‐22; chronic rhinosinusitis; disease severity; olfaction; olfactory disorders; olfactory test; quality of life.

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Conflict of interest statement

Daniel M. Beswick: In the last 36 months. Daniel M. Beswick has received grant support from NIH/NHLBI, CF Foundation, International Society of Inflammation and Allergy of the Nose and the American Rhinologic Society CORE/Sue Ann and John L. Weinberg Foundation; honoraria from sources including from National Jewish Health; consulting fees from Amgen, on medicolegal cases and from Garner Health (equity).

Jeremiah A. Alt: Consultant for OptiNose and Medtronic. Speaker panel GSK. GlycoMira board and equity holder. Kristine A. Smith: In the last 24 months, served as consultant for SanofiGenzyme.

Zachary M. Soler: Consultant for OptiNose, Regeneron, and Lyra; Medical Directory for Healthy Humming. Rodney J. Schlosser: Consultant for OptiNose, Medtronic, Stryker, Cyrano; Medical Directory for Healthy Humming. Jennifer L. Taylor‐Cousar: In the last 36 months, JLT‐C has received grants from the CF Foundation related to this work as well as for work unrelated to the manuscript. Unrelated to this work, she has received grants for her institution from Vertex Pharmaceuticals Incorporated, Eloxx, and 4DMT; received fees from Vertex Pharmaceuticals Incorporated related to consultation on clinical research design, participation on advisory boards, and speaking engagements; and served on advisory boards and/or provided clinical trial design consultation for Insmed, 4DMT, and AbbVie. She serves on a DMC for AbbVie. She serves as the adult patient care representative to the CFF Board of Trustees, and on the CF Foundation's Clinical Research Executive Committee, Clinical Research Advisory Board, Racial Justice Working Group and as immediate past chair of the CF TDN's Sexual Health, Reproduction and Gender Research Working Group, on the scientific advisory board for Emily's Entourage, and on the ATS Respiratory Health Awards, Scientific Grant Review and Clinical Problems Assembly Programming Committees. All other authors declare no conflict of interest.

Figures

**FIGURE 1**
(A and B) Item‐based information of SNOT‐22 items categorized into subdomains with percentage of total information. (A) The horizontal axis represents the percentage of total information in a subdomain. The vertical orange line represents the cut‐off percentage for “above‐average” information, calculated by 100%/number of items in a subdomain. Items with “above‐average” information were retained in the abbreviated surveys. The darker bar in each graph indicates information of all PwCF, while the lighter bar indicates that of PwCF with history of modulator therapy use. (B) The horizontal axis represents the percentage of total information in a subdomain. The six‐ to seven‐item surveys retained the fewest items that encompassed at least 30% of the test information of that subdomain. The darker bar in each graph indicates information of all PwCF, while the lighter bar indicates that of PwCF with history of modulator therapy use.

See this image and copyright information in PMC

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Abridging the 22-Item Sino-Nasal Outcome Test (SNOT-22) in People With Cystic Fibrosis: Limiting Survey Burden

Affiliations

Abridging the 22-Item Sino-Nasal Outcome Test (SNOT-22) in People With Cystic Fibrosis: Limiting Survey Burden

Authors

Affiliations

Conflict of interest statement

Figures

References

Grants and funding

LinkOut - more resources

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