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. 2025 Nov 1;110(11):2774-2778.
doi: 10.3324/haematol.2024.286264. Epub 2025 May 15.

Prognostic impact of the immune microenvironment in multiple myeloma: a meta-analysis of current studies

Nicola Susca  1 , Paola Borrelli  2 , Cirino Botta  3 , Antonio G Solimando  4
Affiliations

Prognostic impact of the immune microenvironment in multiple myeloma: a meta-analysis of current studies

Nicola Susca et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
PRISMA flow-chart. One study (62 patients) examined CD200 expression. Higher expression was associated with worse OS (HR=2.30; 95% CI: 1.20-4.20) (Figure 2).
Figure 2.
Figure 2.
Forest plot for hazard ratios for overall survival of the single cell types, with 95% confidence interval. OS: overall survival; NK: natural killer.
Figure 3.
Figure 3.
Forest plot for the meta-analyses for the cell types whose hazard ratio for overall survival has been reported in more than one study. HR: hazard ratio; OS: overall survival; CI: confidence interval; NK: natural killer.
See this image and copyright information in PMC

References

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    1. Danziger SA, McConnell M, Gockley J, et al. Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: a cohort study of patients in the Total Therapy clinical trials. PLoS Med. 2020;17(11):e1003323. - PMC - PubMed
    1. Lee B-H, Park Y, Kim JH, et al. PD-L1 expression in bone marrow plasma cells as a biomarker to predict multiple myeloma prognosis: developing a nomogram-based prognostic model. Sci Rep. 2020;10(1):12641. - PMC - PubMed
    1. Shi Q, Wu C, Han W, et al. Clinical significance of CD200 expression in newly diagnosed multiple myeloma patients and dynamic changing during treatment. Leuk Lymphoma. 2021;62(3):709-715. - PubMed
    1. Solimando AG, Da Vià MC, Leone P, et al. Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression. Haematologica. 2021;106(7):1943-1956. - PMC - PubMed

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