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Review
. 2025 Jun;95(6):1091-1095.
doi: 10.1111/ans.70157. Epub 2025 May 15.

The Place of Appendicectomy in Inflammatory Bowel Disease-A Review

Krishanth Naidu  1   2   3 , Pearl Wong  1   3 , Pierre H Chapuis  1   2   3 , Matthew J F X Rickard  1   2   3 , Kheng-Seong Ng  1   2   3
Affiliations
Review

The Place of Appendicectomy in Inflammatory Bowel Disease-A Review

Krishanth Naidu et al. ANZ J Surg. 2025 Jun.

Abstract

The aetiology and pathophysiology of inflammatory bowel disease (IBD) are not completely understood; however, a dysregulated intestinal immune system appears key to its pathogenesis. It has been suggested that the appendix is central to nurturing the enteric mucosal system due to its production of lymphoid products and that an appendicectomy may have an immune modulating effect. The aim of this review is to explore the available evidence for the association between IBD and appendicectomy and attempt to define its impact on the incidence and risk of Crohn's disease (CD) and Ulcerative colitis (UC) onset and progression.

Keywords: Crohn's disease; appendicectomy; inflammatory bowel disease; ulcerative colitis.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

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