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Review
. 2025:2920:257-277.
doi: 10.1007/978-1-0716-4498-0_15.

Review of Neuroimaging Methods in ME/CFS

Kiran Thapaliya  1 , Maira Inderyas  2 , Leighton Barnden  2
Affiliations
Review

Review of Neuroimaging Methods in ME/CFS

Kiran Thapaliya et al. Methods Mol Biol. 2025.

Abstract

The brain is the most complex organ in the human body, and is involved in memory, speech, and movement, as well as regulating the functions of many other organs within the body. Various imaging techniques have detected subtle brain changes in vivo in ME/CFS. This chapter explores different neuroimaging studies used to investigate structural, functional, neurochemical, and tissue microstructural alterations in ME/CFS. These include magnetic resonance imaging (MRI), positron emission tomography (PET), and single photon emission computed tomography (SPECT).

Keywords: Brain; ME/CFS; MRI; Neuroimaging; PET; SPECT.

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