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Editorial
. 2025 May 27;9(10):2436-2437.
doi: 10.1182/bloodadvances.2025015863.

Breaking the cycle: PRMTs and secondary HLH relief

Sakshi Malik  1 , Shanmuganathan Chandrakasan  1
Affiliations
Editorial

Breaking the cycle: PRMTs and secondary HLH relief

Sakshi Malik et al. Blood Adv. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: S.C. serves on the advisory board of Sobi and Pharming. S.M. declares no competing financial interests.

Figures

None
sHLH is induced in mice through the administration of CpG-1826 and anti-IL-10R antibodies. Treatment with PRT382, a selective PRMT5 inhibitor, mitigates HLH-associated pathology, including splenomegaly, hepatomegaly, and anemia, while normalizing IFN-γ and IL-6 levels.
See this image and copyright information in PMC

Comment on

  • PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis.
    Brown-Burke F, Saadey R, Mao HC, Marra P, Brooks E, Wandtke A, Hout I, Leon S, Sharma A, Yasin A, Cash T, Ahmed EH, Baiocchi E, Finoti S, Zhang X, Bhagwat N, Vaddi K, Scherle P, Mozhenkova A, El-Ayachi I, Schenk AD, Sloan SL, Whitman K, Helmig-Mason J, Steyn S, Klimaszewski HL, Weist J, Weigel C, Koirala S, Alinari L, Snyder K, Ranganathan P, Chen CJ, Jordan MB, Baiocchi RA, Shindiapina P. Brown-Burke F, et al. Blood Adv. 2025 May 27;9(10):2379-2392. doi: 10.1182/bloodadvances.2024013651. Blood Adv. 2025. PMID: 39825858 Free PMC article.

References

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