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Editorial
. 2025 Jun;49(6):102613.
doi: 10.1016/j.clinre.2025.102613. Epub 2025 May 13.

Precision oncology in colorectal cancer: An anatomical revolution through molecular-clinical integration across colonic subsites

Jiefeng Zhao  1 , Daxing Miao  2
Affiliations
Editorial

Precision oncology in colorectal cancer: An anatomical revolution through molecular-clinical integration across colonic subsites

Jiefeng Zhao et al. Clin Res Hepatol Gastroenterol. 2025 Jun.

Abstract

Colorectal cancer (CRC) exhibits significant heterogeneity across different colonic subsites, which vary in embryological origin, microbiome, metabolome, and molecular profiles, affecting tumorigenesis, treatment response, and prognosis. We emphasize the importance of this subsite heterogeneity to advance precision medicine in CRC.

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Declaration of competing interest We have no conflict of interests.

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