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. 2025 Nov;57(11):3799-3809.
doi: 10.1007/s11255-025-04561-8. Epub 2025 May 15.

Correlation between parathyroid volume and calcium and phosphorus metabolism in maintenance hemodialysis patients based on Doppler ultrasound technology

Shengjie Guo  1 , Liping Liu  1 , Chao Zou  1 , Pingping Liang  2 , Yurou Wang  3 , Chengcheng Sun  1 , Xiaosu Gan  1 , Xiaofang Tian  4 , Liying Yuan  5
Affiliations

Correlation between parathyroid volume and calcium and phosphorus metabolism in maintenance hemodialysis patients based on Doppler ultrasound technology

Shengjie Guo et al. Int Urol Nephrol. 2025 Nov.

Abstract

Objectives: To investigate the correlation between parathyroid glands (PTGs) volume and calcium and phosphorus metabolism in maintenance hemodialysis (MHD) patients with Doppler ultrasound.

Methods: MHD patients at the Hemodialysis Center of the Third Affiliated Hospital of Zunyi Medical University from January 1, 2024, to January 31, 2024, were selected as study subjects. To investigate the correlation between the number and size of PTGs detected by bedside ultrasound and indicators of calcium and phosphorus metabolism.

Results: A total of 135 patients were included, of whom 90 had explored hyperplastic PTGs and 45 did not. Correlation analysis showed a negative correlation between ultrasound total PTGs volume and with age (r = -0.222, P = 0.035), large platelet ratio (r = -0.262, P = 0.013), and mean platelet volume (r = -0.232, P = 0.028), and a positive correlation with parathyroid hormone (iPTH) (r = 0.268, P = 0.011), corrected serum calcium (r = 0.233, P = 0.027), taking cinacalcet (r = 0.252, P = 0.0.017), sevelamer carbonate (r = 0.352, P = 0.002) and compound α-ketoacid tablets (r = 0.478, P < 0.001). Multifactorial linear regression analysis showed a positive correlation between ultrasound total PTGs volume and the correlation with age (t = -3.071, 95% CI: -0.030 ~ -0.007), albumin (t = -2.242, 95% CI: -0.115 ~ -0.008), iPTH (t = 2.748, 95% CI: 0.001 ~ 0.002), corrected serum calcium (t = 2.484, 95% CI: 0.184 ~ 1.563) showed significant linear relationships.

Conclusions: A significant linear correlation was observed between PTGs volume, assessed via Doppler ultrasound, and the variables of age, albumin, iPTH, and corrected serum calcium in MHD patients. Therefore, it is essential for MHD patients to be closely monitored and have these serological indices controlled.

Keywords: Calcium and Phosphorus metabolism; Doppler ultrasound; Maintenance hemodialysis; Parathyroid gland; Secondary hyperparathyroidism (SHPT).

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

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